Results 81 to 90 of about 32,896 (166)
Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity
Advanced Science, Volume 13, Issue 16, 18 March 2026.Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu +5 more
wiley +1 more source
The effect of feeding a low iron diet prior to and during gestation on fetal and maternal iron homeostasis in two strains of rat [PDF]
, 2013 Background Iron deficiency anaemia during pregnancy is a global problem, with short and long term consequences for maternal and child health. Animal models have demonstrated that the developing fetus is vulnerable to maternal iron restriction, impacting
Cornock, Ruth +4 more
core +4 more sources
Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?
Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin +11 more
wiley +1 more source
A hem érfal komponensekre kifejtett közvetlen és közvetett patofiziológiai hatásai = Pathologic effects of heme on components of vessel wall via direct and indirect mechanisms [PDF]
, 2010 Kimutattuk, hogy az atheroma lipid magja prooxidáns környezetet teremt, ahol a vörösvértestek szétesnek, a hemoglobin ferri- és ferrylhemoglobinná oxidálódik, és a felszabaduló hem és vas lipidoxidációt indít el.
Balla, György +5 more
core
CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.The current study uncovered aggravated cerebral ischemic injury and neurological dysfunction following diabetic stroke, in which ferroptosis was involved. SLC7A11 expression was inhibited in the early stages of reperfusion during diabetic stroke, and both ferroptosis inhibitors and neuron‐specific enforced expression of SLC7A11 mitigated neuronal lipid
Siyuan Liu +13 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 3, March 2026.ABSTRACT Background and Aims Chronic inflammation contributes to various chronic diseases, emphasizing the need for reliable biomarkers for early detection and understanding its causes. Measuring chronic inflammation poses challenges since most biomarkers are influenced by both acute and chronic states and recent exposures.
Gary Sánchez‐Gordón +7 more
wiley +1 more source
Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births. [PDF]
, 2019 Preterm birth (PTB) is leading contributor to infant death in the United States and globally, yet the underlying mechanistic causes are not well understood.
Ackerman, William E +6 more
core +3 more sources
Diagnosis and treatment of hepatolenticular degeneration
Медицинский совет, 2013 Hepatolenticular degeneration (Wilson-Konovalov disease or hepatolenticular disease) is a rare hereditary disease caused by impaired copper metabolism and copper accumulation in the liver and, subsequently, in other organs.
V. V. Skvortsov, O. A. Leshina
doaj +1 more source
Veterinary and Comparative Oncology, Volume 24, Issue 1, Page 128-139, March 2026.ABSTRACT Mammary carcinomas are aggressive neoplasms and a significant cause of mortality in female cats. Despite surgical removal, feline mammary carcinoma (FMC) often recurs or metastasizes. Specific tumour biomarkers are necessary for early detection, prognosis and therapy selection.
Pruettha Aruvornlop +7 more
wiley +1 more source