Results 221 to 230 of about 42,575 (291)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

A novel methylation marker on the <i>CLEC14A</i> gene for cervical cancer screening. [PDF]

Front Oncol
Wang S, Xiao H, Gao H.
europepmc   +1 more source

17. Cancer Pain: Part I: Cordotomy for Unilateral Pain due to Cancer

Pain Practice, Volume 26, Issue 6, July 2026.
ABSTRACT Introduction Despite advancements in pharmacological and intrathecal treatment of oncological pain, it remains a significant challenge, affecting 44.5% of patients with cancer, with 30.6% experiencing moderate‐to‐severe pain. Methods This scoping review provides a summary of the literature from 2016 to 2024, focusing on percutaneous cordotomy ...
Bregje Huisman, Martine Puylaert, Liong Liem, Manohar Sharma, Johannes C. F. Ket, Steven P. Cohen, Kris Vissers, Monique Steegers   +7 more
wiley   +1 more source

Double vertebral artery-connected persisting proatlantal artery coexisting with a persisting carotid duct in an adult case: first evidence. [PDF]

Surg Radiol Anat
Rusu MC, Jianu AM, Grigoriţă LO, Tudose RC.   +3 more
europepmc   +1 more source

Integrative Multi‐Omics Analysis Elucidates the Progressive Disease Landscape and Reveals Dynamic Protein Biomarkers for MASLD Surveillance

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Integrated transcriptomic, single‐cell, pseudotime, cell–cell communication, human tissue, and in vivo analyses define a dynamic four‐gene axis across the MASLD continuum. Progressive CYP2C19 downregulation and AKR1B10, COL1A2, and SPP1 upregulation link metabolic dysfunction to disease progression, while AKR1B10 knockdown or CYP2C19 overexpression ...
Kejun Liu, Bozhi Zhang, Yezhen Tang, Zhenyao Tan, Yang Bu, Yongxue Lv   +5 more
wiley   +1 more source

The prevalence of unclosed transverse foramina in the cervical spine of a South African population sample. [PDF]

Surg Radiol Anat
Nalla S, Noorbhai N, Paton GJ.
europepmc   +1 more source

Reduced Cerebral Blood Flow in the Early Chronic Phase of Recurrent Concussion Among Female Collegiate‐Aged Athletes

Human Brain Mapping, Volume 47, Issue 9, June 15, 2026.
In a sample of healthy collegiate‐aged athletes, we observed that greater lifetime concussion history was associated with global and frontotemporal hypoperfusion, an effect seen exclusively in female athletes. These findings suggest a potentially modifiable, sex‐specific marker that could support earlier detection and intervention in concussion‐related
Mitchell J. Andersson, Bryna D. Goeckner, Lezlie Y. España, Andrew R. Mayer, Benjamin L. Brett, Timothy B. Meier   +5 more
wiley   +1 more source

Integrated Multi-Omics Analysis Constructs an Intratumoral Heterogeneity-Corrected Prognostic Signature for Cervical Cancer. [PDF]

Int J Gen Med
Tang X, Zheng Q, Li X, Wang K.
europepmc   +1 more source

Different Expressions and Methylation Patterns of cGAS and STING in Cervical Cancer. [PDF]

Obstet Gynecol Int
Wang R, Liu S, Wang R, Guo Q, Lu X.
europepmc   +1 more source

CT Anatomical and Morphometric Study of the Red Fox (<i>Vulpes Vulpes</i>): Cervical Vertebrae. [PDF]

Vet Med Int
Valizadeh Y, Abbasi M, Zehtabvar O, Zakian A, Vajhi AR, Fekri F.   +5 more
europepmc   +1 more source