Results 121 to 130 of about 415,432 (310)

Bioorthogonal Photoactivation of 2‐Nitrobenzyl Caged Doxorubicin Anticancer Prodrugs on Gold Nanostars

Advanced Materials, EarlyView.
Bioorthogonal chemistry was applied to intracellularly photoactivate Doxorubicin (Dox) using gold nanostars (AuNSt) and near‐infrared (NIR) light. Two prodrugs were used: one photoactivatable, masked with 2‐nitrobenzyl carbamate (proDox1) and another photolabile, masked with 2‐nitrobenzyl diol (proDox2), which was attached to the AuNSt surface.
Juan José Esteve‐Moreno, Andrea Escudero, Oscar Ferreira Silvestre, José Manuel Terrés, Mónica Gorbe, Eva Garrido, Carlos Renero‐Lecuna, Judith Langer, María Alfonso, Javier Ibañez, Félix Sancenón, Roberto Cao‐Milán, Luis M. Liz‐Marzán, Alba García‐Fernández, Andy Hernández‐Montoto, Ramón Martínez‐Máñez   +15 more
wiley   +1 more source

General Practitioners knowledge, views and practices regarding cervical cancer screening in Australia. CHERE Working Paper 2010/6 [PDF]

Objective General practitioners (GPs) are the main providers of cervical screening in Australia and are crucial to the successful implementation of the National Cervical Screening Program (NCSP).
Marion Haas, Stephen Goodall, Rosalie Viney   +2 more
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HPV vaccination willingness and behavior among patients with cervical intraepithelial neoplasia in low-resource areas of Western China: a cross-sectional study

Frontiers in Public Health
BackgroundResearch on human papillomavirus (HPV) vaccination willingness and behavior among patients with cervical intraepithelial neoplasia (CIN) remains limited, although such evidence is essential for improving disease prevention.MethodsA knowledge ...
Kefan Jiang, Yawen Shao, Huiling Wang, Fanghui Zhao, Li Su, Chengyun Li, Haitao Ma, Shumei Tuo, Ru Lin, Junling Wang   +9 more
doaj   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Nationwide implementation and evaluation of an external quality assessment program for HPV screening in Peru

International Journal of Infectious Diseases
In the global effort to eliminate cervical cancer, high-quality Human Papillomavirus (HPV) testing is essential, especially in Peru where vaccination coverage remains incomplete. To ensure consistent nationwide test performance, the Peruvian HPV National
Pamela Rios-Monteza, Lesly Solis-Ponce, Susan Espetia, Carina Eklund, Laila Sara Arroyo Mühr, Joakim Dillner, Andrea Matos, Maribel Acuña, George Obregon   +8 more
doaj   +1 more source

Reprogramming the Immunosuppressive Microenvironment in Triple‐Negative Breast Cancer via FAP‐Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy

Advanced Materials, EarlyView.
Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan, Yanhong Chen, Jingjing Hu, Chunting Wang, Huanhuan Liu, Defan Yao, Dengbin Wang   +6 more
wiley   +1 more source

A High‐Resolution THz‐PCF Sensing Framework: Precise Identification of Food Preservatives Through Refractive Index Analysis

Advanced Materials Interfaces, EarlyView.
As presented in the graphical abstract, it depicts an image of a terahertz photonic crystal fiber (THz‐PCF) sensor with a polygonal shape in the core, which is filled with an analyte, and air slots in the cladding. The THz waves will travel through the fiber, and due to increased light‐matter interaction in the sensing region, changes in refractive ...
T. H. M. Sumon Rashid, Md. Nayem Hossain, Md. Golam Kibria, A. H. M. Iftekharul Ferdous, Jabin Tasnin Upoma, Md. Lalon Hossain, Sajad Ali   +6 more
wiley   +1 more source

Post-conization pathological upgrading and outcomes of 466 patients with low-grade cervical intraepithelial neoplasia

Frontiers in Oncology
IntroductionThe management of patients with low-grade cervical intraepithelial neoplasia (CIN1) remains controversial. We analyzed the pathological upgrading rates of patients with CIN1 undergoing conization, identifying influencing factors, and compared
Yulin Guo, Yulin Guo, Hongning Cai, Hongning Cai, Qiuzi Peng, Qiuzi Peng, Ying Wang, Ying Wang, Lu Li, Lu Li, Miao Zou, Miao Zou, Jinyue Guo, Jinyue Guo, Chaonan Wang, Chaonan Wang, Xufeng Wu, Xufeng Wu, Quanfu Ma, Quanfu Ma   +19 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Report on monitoring activities of the National Cervical Screening Program Safety Monitoring Committee [PDF]

, 2013
This report looks at the evidence collected and assessed by the Safety Monitoring Committee established to assess whether there were adverse outcomes following the introduction of new guidelines on how women with a low-grade Pap test result or a ...

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