Results 51 to 60 of about 718,452 (353)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Exponential uptake of HPV self-collected cervical screening testing 2 years since universal availability in Victoria, Australia

BMC Medicine
Background Australia is working towards eliminating cervical cancer as a public health issue by 2035, by achieving an incidence rate of less than 4 cases per 100,000 people.
Alvin Lee, David Hawkes, Daniel Sweeney, Kerryann Wyatt, Claire Nightingale, Corey Chalmers, Marion Saville   +6 more
doaj   +1 more source

Interobserver variability and accuracy of p16/Ki-67 dual immunocytochemical staining on conventional cervical smears

Diagnostic Pathology, 2019
Background p16/Ki-67 dual immunocytochemical staining (DS) has been proven as a sensitive and specific test for triage of HPV positive women with good reproducibility and accuracy.
Veronika Kloboves Prevodnik, Tine Jerman, Nataša Nolde, Alenka Repše Fokter, Sandra Jezeršek, Živa Pohar Marinšek, Ulrika Klopčič, Simona Hutter Čelik, Kristina Gornik Kramberger, Maja Primic Žakelj, Urška Ivanuš   +10 more
doaj   +1 more source

Computer-Aided Detection of Pathologically Enlarged Lymph Nodes On Non-Contrast CT In Cervical Cancer Patients For Low-Resource Settings [PDF]

, 2017
The mortality rate of cervical cancer is approximately 266,000 people each year, and 70% of the burden occurs in Low- and Middle- Income Countries (LMICs). Radiation therapy is the primary modality for treatment of locally advanced cervical cancer cases.
Anderson, Brian M, Court, Laurence E, Cressman, Erik, Johnson, Jennifer, Klopp, Ann, Kry, Stephen F, Rao, Arvind, Yang, Jinzhong   +7 more
core   +1 more source

Determinants of Acceptance of Cervical Cancer Screening in Dar es Salaam, Tanzania. [PDF]

, 2012
To describe how demographic characteristics and knowledge of cervical cancer influence screening acceptance among women living in Dar es Salaam, Tanzania. Multistage cluster sampling was carried out in 45 randomly selected streets in Dar es Salaam. Women
A Hildesheim, AB Miller, AP Vizcaino, B Palanuwong, BA Johnson, Britt Tersbol, C Sepulveda, Crispin Kahesa, E Lazcano-Ponce, F Guidozzi, FX Bosch, H Nabudere, HL Kidanto, HR Wabinga, IARC, J Bradley, J Cuzick, J Ferlay, JBF Ferlay, Julius Mwaiselage, K Deodhar, L Denny, M Dartell, M Hakama, Myassa Dartell, N Munoz, P Autier, P Sasieni, Path, R Sankaranarayanan, SA Francis, SC Mupepi, SK Kjaer, SU Mbamara, Susanne Kjaer, T Ngoma, Twalib Ngoma, Vibeke Rasch, YL Qiao   +38 more
core   +2 more sources

Cervical Cancer Screening [PDF]

Journal of the National Comprehensive Cancer Network, 2010
These NCCN Guidelines Insights focus on recent recommendations for cervical cancer screening and management of abnormal screening tests. When the NCCN Panel convened to update the NCCN Guidelines for Cervical Cancer Screening, they decided to adopt and endorse guidelines from other organizations to avoid duplication of effort.
Edward E, Partridge, Nadeem R, Abu-Rustum, Susan M, Campos, Patrick J, Fahey, Michael, Farmer, Rochelle L, Garcia, Anna, Giuliano, Howard W, Jones, Subodh M, Lele, Richard W, Lieberman, Stewart L, Massad, Mark A, Morgan, R Kevin, Reynolds, Helen E, Rhodes, Diljeet K, Singh, Karen, Smith-McCune, Nelson, Teng, Cornelia Liu, Trimble, Fidel, Valea, Sharon, Wilczynski   +19 more
openaire   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Expanding management strategies for cervical precancerous lesions in resource-limited settings: insights from a training center in a district hospital in Ghana

BMC Women's Health
Background Cervical cancer continues to disproportionately burden women in low/middle-income countries like Ghana. We examined treatment patterns and histopathological outcomes among women screened using visual inspection with acetic acid (VIA) and/or ...
Kofi Effah, Ethel Tekpor, Comfort Mawusi Wormenor, Samuel Adolf Bosoka, Maxwell Afetor, Anita Edinam Dugbazah, Stephen Danyo, Esu Aku Catherine Morkli, Georgina Tay, Bernard Hayford Atuguba, Elorm Kpofo-Tetteh, Chrysantus Kubio, Nana Owusu Mensah Essel   +12 more
doaj   +1 more source

CIN coexisting with AIS is a risk factor for residual disease after conization for cervical adenocarcinoma in situ

Frontiers in Oncology
IntroductionCompared to definitive hysterectomy, cervical conization with negative margin remains a controversial management for AIS currently. Our study aimed to evaluate (1) the effect of conization with negative margin alone or subsequent hysterectomy,
Rong Zeng, Yulin Guo, Miao Zou, Chaonan Wang, Xufeng Wu   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source