Results 71 to 80 of about 638,968 (308)

Exploring the acceptability of two self-sampling devices for human papillomavirus testing in the cervical screening context: a qualitative study of Muslim women in London [PDF]

, 2010
Objectives We explored Muslim women's attitudes to self-sampling for human papillomavirus (HPV) in the context of cervical cancer screening and their responses to two self-sampling devices.Setting A Muslim community centre in north-east London.Methods ...
Ashdown-Barr, L, Cadman, L, Szarewski, A, Waller, J   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Interobserver variability and accuracy of p16/Ki-67 dual immunocytochemical staining on conventional cervical smears

Diagnostic Pathology, 2019
Background p16/Ki-67 dual immunocytochemical staining (DS) has been proven as a sensitive and specific test for triage of HPV positive women with good reproducibility and accuracy.
Veronika Kloboves Prevodnik, Tine Jerman, Nataša Nolde, Alenka Repše Fokter, Sandra Jezeršek, Živa Pohar Marinšek, Ulrika Klopčič, Simona Hutter Čelik, Kristina Gornik Kramberger, Maja Primic Žakelj, Urška Ivanuš   +10 more
doaj   +1 more source

Computer-Aided Detection of Pathologically Enlarged Lymph Nodes On Non-Contrast CT In Cervical Cancer Patients For Low-Resource Settings [PDF]

, 2017
The mortality rate of cervical cancer is approximately 266,000 people each year, and 70% of the burden occurs in Low- and Middle- Income Countries (LMICs). Radiation therapy is the primary modality for treatment of locally advanced cervical cancer cases.
Anderson, Brian M, Court, Laurence E, Cressman, Erik, Johnson, Jennifer, Klopp, Ann, Kry, Stephen F, Rao, Arvind, Yang, Jinzhong   +7 more
core   +1 more source

How the Cervical Microbiota Contributes to Cervical Cancer Risk in Sub-Saharan Africa [PDF]

, 2020
Despite ongoing efforts, sub-Saharan Africa faces a higher cervical cancer burden than anywhere else in the world. Besides HPV infection, definitive factors of cervical cancer are still unclear.
Angeletti, Peter C., Kahesa, Crispin, Klein, Cameron, Mwalselage, Julius, West, John T., Wood, Charles   +5 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Expanding access to HPV screening through community health insurance schemes: lessons from a screening exercise for teachers in Ghana

BMC Health Services Research
Background Cervical cancer (CC) screening uptake remains low primarily owing to the absence of organized screening and lack of insurance coverage. Members of the Ghana National Association of Teachers (GNAT) contribute monthly to an insurance scheme ...
Kofi Effah, Ethel Tekpor, Joseph Emmanuel Amuah, Elagbe Goka, Comfort Mawusi Wormenor, Richard Armah, Seyram Kemawor, Stephen Danyo, Annita Edinam Dugbazah, Nana Owusu Mensah Essel, Emmanuel Timmy Donkoh   +10 more
doaj   +1 more source

Human papillomavirus-based cervical screening and long-term cervical cancer risk: a randomised health-care policy trial in Sweden

The Lancet Public Health
Summary: Background: Human papillomavirus (HPV)-based cervical screening is a globally recommended public health policy. Randomised clinical trials find superior performance of primary HPV-based screening compared with cytology for preventing cervical ...
Jiangrong Wang, PhD, K Miriam Elfström, PhD, Joakim Dillner, ProfMD   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source