Results 141 to 150 of about 2,510,677 (328)

Knowledge and Risk Factors of Intraepithelial Lesion amongst Women of Childbearing Age in Jos, Nigeria

Journal of Applied Sciences and Environmental Management
Cervical cancer is a major public health issue worldwide, particularly in low- and middle-income countries. Persistent infection with human papilloma virus (HPV) has been implicated in causing cervical cancer through sexual contact.
Y. Selji, J. O. Adisa, S. M. Gamde, K. I. Bali, M. S. Udo, C. A. Ikeh   +5 more
doaj   +4 more sources

Morphological irregularity of tracheal rings in horses, associated or not with cervical malformation

Pubvet
With the purpose of verifying the existence of irregularities in the tracheal rings of horses and correlating it with the presence of equine cervical vertebral malformation, 45 horses were used, including males and females of different breeds ...
Luiz Alberto da Silva Vasconcellos
doaj   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Prevalence of cervical intraepithelial lesions and associated factors among women attending a cervical cancer clinic in Western Uganda; results based on Pap smear cytology

SAGE Open Medicine
Introduction: There are high incidence and mortality rates of cervical cancer among females in East Africa. This is exacerbated by limited up-to-date data on premalignant lesions and associated factors in this setting.
Frank Ssedyabane, Nixon Niyonzima, Josephine Nambi Najjuma, Abraham Birungi, Raymond Atwine, Deusdedit Tusubira, Thomas C Randall, Cesar M Castro, Hakho Lee, Joseph Ngonzi   +9 more
doaj   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Liquid-based cytology - new possibilities in the diagnosis of cervical lesions [Tekuća citologija - nove mogućnosti u dijagnostici lezija vrata maternice] [PDF]

, 2010
Liquid-based cytology (LBC) enables the use of supplementary methods in the diagnosis and prognosis of cervical lesions. The aim of this study was to analyze the correlation between p16INK4a immunoexpression in ThinPrep cervical cytologic samples and ...
Babić, Damir, Barišić, Ana, Jurič, Danijela, Mahovlić, Vesna, Orešković, Slavko, Ovanin-Rakić, Ana, Rajhvajn, Sanda, Suša, Martina, Ćorušić, Ante, Šamija Projić, Ivana, Škopljanac-Mačina, Lada   +10 more
core  

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Association between HIV Serostatus and premalignant cervical lesions among women attending a cervical cancer screening clinic at a tertiary care facility in southwestern Uganda: a comparative cross-sectional study

BMC Women's Health
Background Uganda has approximately 1.2 million people aged 15–64 years living with human immunodeficiency virus (HIV). Previous studies have shown a higher prevalence of premalignant cervical lesions among HIV-positive women than among HIV-negative ...
Justus Kirabira, Musa Kayondo, Stephen Mayanja Bawakanya, Edirisa Juniour Nsubuga, Fajardo Yarine, Alexcer Namuli, Rita Namugumya, Christine Hilda Natulinda, Raymond Atwine, Abraham Birungi, Henry Mark Lugobe, Leevan Tibaijuka, Dean Kisombo, Mark Jjuuko, David Collins Agaba, Pascal Saturday, Subira Mlangwa Atupele, Matthew Tumusiime, Richard Migisha, Rogers Kajabwangu   +19 more
doaj   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source