Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development
Abstract Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Their critical role in the establishment of a left–right axis in early development is well described, as well ...
Stephen Spurgin+8 more
wiley +1 more source
The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity [PDF]
Jatin P. Shah+2 more
openalex +1 more source
STIP1 drives Metabolic Reprogramming in Esophageal Squamous Cell Carcinoma via AHCY‐LDHA Axis
A schematic model illustrating that LCA can inhibit ESCC growth by inhibiting the STIP1/AHCY/LDHA axis. In brief. Jin et al. demonstrated that targeting STIP1 can significantly inhibit the progression of esophageal squamous cell carcinoma. The high expression of STIP1 increased the interaction between AHCY and LDHA and then AHCY recruits PRMT3 to ...
Guoguo Jin+16 more
wiley +1 more source
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4. [PDF]
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments.
Alexandrov, Ludmil B+18 more
core
Prognostic Factors for Free Flap Failure in Head and Neck Reconstruction
ABSTRACT Background The failure rate of free flaps varies from 0.8% to 10.6% in the literature in head and neck reconstruction. The primary objective was to identify prognostic factors for free flap failure. Methods We prospectively included all consecutive free flaps performed between August 2021 and January 2024, and used a multivariate Cox ...
Quentin Hennocq+10 more
wiley +1 more source
The Application of Deep Learning for Lymph Node Segmentation: A Systematic Review [PDF]
Automatic lymph node segmentation is the cornerstone for advances in computer vision tasks for early detection and staging of cancer. Traditional segmentation methods are constrained by manual delineation and variability in operator proficiency, limiting their ability to achieve high accuracy.
arxiv
Emperipolesis in a Case of Adult T Cell Lymphoblastic Lymphoma (Mediastinal type)-Detected at FNAC and Imprint Cytology [PDF]
Emperipolesis is a condition in which viable hematopoetic cells are seen intact in the cytoplasm of host cell without damage. This phenomenon is seen in many physiologic and pathologic conditions, its presence in Rosai Dorfman disease (RDD) is ...
Abhishekh, MG+3 more
core
Factors Increasing the Likelihood of Postoperative Hematomas Following Thyroid Surgery
ABSTRACT Background Neck hematoma following thyroid surgery is a potentially life‐threatening complication. Methods This retrospective case–control study reviewed neck hematoma reoperations following thyroid surgery (2009–2024), using 3:1 matching. Univariable analysis identified hematoma and delayed onset (≥ 6 h) risk factors, with odds ratios (ORs ...
Emily Ajit‐Roger+9 more
wiley +1 more source
Correlation between Load of HPV 16 DNA in Cervical Cancer and HPV 16 DNA in Lymph Nodes
OBJECTIVE To determine the association between viral load of human papillomavirus 16 (HPV16) DNA in the primary focus of cervical carcinoma and HPV16 DNA in pelvic lymph nodes.METHODS The HPV16 DNA load was measured by fluorescent quantitation ...
Shuzhen DAI, Ding MA, Weidong QU
doaj +1 more source
WeGA: Weakly-Supervised Global-Local Affinity Learning Framework for Lymph Node Metastasis Prediction in Rectal Cancer [PDF]
Accurate lymph node metastasis (LNM) assessment in rectal cancer is essential for treatment planning, yet current MRI-based evaluation shows unsatisfactory accuracy, leading to suboptimal clinical decisions. Developing automated systems also faces significant obstacles, primarily the lack of node-level annotations. Previous methods treat lymph nodes as
arxiv