Results 51 to 60 of about 7,145 (238)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Vaginal Misoprostol for Cervical Ripening in Term Pregnancy [PDF]

, 2006
Low-dose (25 mcg) intravaginal misoprostol appears to be safe and effective for cervical ripening in term pregnancy for patients without a history of cesarean section.
Cook, Jessica, Nashelsky, Joan, Weaver, Sally P.   +2 more
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Delineation of VEGF-regulated genes and functions in the cervix of pregnant rodents by DNA microarray analysis [PDF]

, 2008
Background VEGF-regulated genes in the cervices of pregnant and non-pregnant rodents (rats and mice) were delineated by DNA microarray and Real Time PCR, after locally altering levels of or action of VEGF using VEGF agents, namely siRNA, VEGF receptor ...
Chishimba N Mowa, Tianbo Li, Subrina Jesmin, Hans G Folkesson, Sharon E Usip, Raymond E Papka, Guichuan Hou, PC Leppert, VN Breeveld-Dwarkasing, JRG Challis, GC Liggins, EH Luque, N Ferrara, C De Vries, M Shibuya, N Ferrara, CN Mowa, S Jesmin, CN Mowa, L Dussably, S Harada, L Ma, H Tokuda, N Ferrara, S Esser, Y Feng, T Murohara, G Celia, E Dejana, S Esser, HM Wu, HM Wu, A Newell, E El Maradny, TC Laurent, J Anderson, RA Word, BC Timmons, KJ Straach, DT Connolly, HF Dvorak, HF Dvorak, RV Stan, ED Albrecht, S Epstein, CG Barclay, R Pfundt, MS Mahendroo, DA Minjarez, L Burger, JM Hastings, J Folkman, KR Brown, JM Krum, J Rak, N Weidner, H Eagle, JC Schaer   +57 more
core   +2 more sources

Outpatient Cervical Ripening

Obstetrics & Gynecology, 2021
OBJECTIVE: To assess the comparative effectiveness and potential harms of cervical ripening in the outpatient compared with the inpatient setting, or different methods of ripening in the outpatient setting alone. DATA SOURCES: Searches for articles in English included MEDLINE ...
McDonagh, Marian, Skelly, Andrea C., Tilden, Ellen, Brodt, Erika D., Dana, Tracy, Hart, Erica, Kantner, Shelby N., Fu, Rongwei, Hermesch, Amy C.   +8 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Cervical preparation for first trimester surgical abortion. [PDF]

, 2010
BACKGROUND: Preparing the cervix prior to surgical abortion is intended to make the procedure both easier and safer. Options for cervical preparation include osmotic dilators and pharmacologic agents.
Hayes, Jennifer L, Kapp, Nathalie, Lohr, Patricia A, Ngo, Thoai D   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Environmental contaminants exposure and preterm birth: a systematic review [PDF]

, 2019
Preterm birth is an obstetric condition associated with a high risk of infant mortality and morbidities in both the neonatal period and later in life, which has also a significant public health impact because it carries an important societal economic ...
Benedetti Panici, Pierluigi, MASCIULLO, LUISA, Piacenti, Ilaria, Porpora, Maria Grazia, Rech, Francesco, Scaramuzzino, Sara   +5 more
core   +1 more source

Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening

Reproductive Biology and Endocrinology, 2022
Background Preterm birth (PTB) is the primary cause of infant morbidity and mortality. Moreover, previous studies have established that PTB is related to premature cervical ripening. However, the underlying mechanism remains to be elucidated.
Yan Yan, Zhuorong Gu, Baihe Li, Xirong Guo, Zhongxiao Zhang, Runjie Zhang, Zheng Bian, Jin Qiu   +7 more
doaj   +1 more source