Results 161 to 170 of about 163,432 (256)

Sustained impact of bivalent HPV immunisation on CIN incidence over two rounds of cervical screening. [PDF]

Int J Cancer
Palmer TJ, Kavanagh K, Cuschieri K, Cameron RL, Graham C, Wilson A, Roy K.   +6 more
europepmc   +1 more source

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

Advanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru, Keiichi Motoyama, Yuting Wen, Zhongxing Zhang, Xuehao Tian, Jun Li, Taishi Higashi   +6 more
wiley   +1 more source

Why do the Nordic countries allow colposcopy to be a weak link in the cervical cancer screening chain?

Acta Obstetricia et Gynecologica Scandinavica
Ilkka Kalliala, Hanna Milerad, Ameli Ellen Claesdotter Trope, Anne Hammer   +3 more
doaj   +1 more source

Retrospective analysis of cervical screening abnormalities in women with type 3 transformation zone without visible lesions. [PDF]

PeerJ
Yang J, Liu Q, Tang Y, Huang K, Chen T, Zhao J.   +5 more
europepmc   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

A Prospective Study to Assess the Utility of Artificial Intelligence-driven Cervical Screening Using Smart Scope versus Conventional Method. [PDF]

J Midlife Health
Dhar S, Saha MM, Sarkar S, Sarkar NC, Das SK, Dutta S.   +5 more
europepmc   +1 more source

Endobody: Genetically Encodable Nanobody‐CPP Chimeras for Degradation of Membrane and Extracellular Proteins

Advanced Science, EarlyView.
We introduced genetically encodable, receptor‐independent nanobody‐CPP chimeras, termed endobodies, as robust and modular membrane protein degraders. Additionally, proteasome‐targeting domain (PTD)‐tethered endobody demonstrates further enhanced degradation potency.
Chengjian Zhou, Huiping He, Simin Xia, Xi Chen   +3 more
wiley   +1 more source

Enhancing equity and efficiency in cervical screening uptake: a multidisciplinary quality improvement initiative. [PDF]

BMJ Open Qual
Santos C, Roye J, Tucker J, Guevara C.
europepmc   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

How would Australian women and people with a cervix like to access self-collection for cervical screening? Screening preferences from a national survey. [PDF]

Cancer Causes Control
Bavor C, Jennett C, Phillips E, Mitchell L, Saunders T, Whop L, Kelly-Hanku A, Bateson D, Brotherton JML, Smith MA, Nightingale C.   +10 more
europepmc   +1 more source