Results 201 to 210 of about 163,432 (256)

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

The Design and Evaluation of Community-Informed Video Resources to Promote Safe and Inclusive Cervical Screening for South Australian LGBTIQ+ People With a Cervix. [PDF]

Health Promot J Austr
Baldock J, Shipley T, Paterson V.
europepmc   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Initial evaluation of a new cervical screening strategy combining human papillomavirus genotyping and automated visual evaluation: the Human Papillomavirus-Automated Visual Evaluation Consortium. [PDF]

J Natl Cancer Inst
Befano B, Kalpathy-Cramer J, Egemen D, Inturrisi F, Jeronimo J, Rodríguez AC, Campos N, Cremer M, Ribeiro A, Ajenifuja KO, Goldstein A, Haider A, Yeates K, Madeleine M, Norris T, Figueroa J, Alfaro K, Raiol T, Adepiti C, Norman J, Chilinda GK, Mchome B, Donastorg Y, Dlamini X, Conzuelo G, Banjo AA, Chone P, Mremi A, Benitez A, Rosberger Z, Vantha T, Prieto-Egido I, Boyd-Morin J, Clark C, Kinder S, Wentzensen N, Desai K, Perkins R, de Sanjosé S, Schiffman M, PAVE Consortium .   +40 more
europepmc   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Nationwide registry-based trial of risk-stratified cervical screening. [PDF]

Int J Cancer
Arroyo Mühr LS, Wang J, Hassan SS, Yilmaz E, Elfström MK, Dillner J.   +5 more
europepmc   +1 more source

The acceptability, safety, and performance of primary cervical screening through self-collected vaginal samples in an urban teaching hospital antenatal clinic setting. [PDF]

PLOS Glob Public Health
Khoo SP, Bouniu JJ, Sivaram L, Hawkes D, Tan PC, Saville M, Woo YL.   +6 more
europepmc   +1 more source

Optimizing the Harms and Benefits of Cervical Screening in a Partially Vaccinated Population in Ontario, Canada: A Modeling Study. [PDF]

Med Decis Making
de Bondt DD, Jansen EEL, Stogios C, McCurdy BR, Kupets R, Murphy J, Costescu D, Rabeneck L, Truscott R, Hontelez JAC, de Kok IMCM.   +10 more
europepmc   +1 more source

HPV vaccine impact: genotype-specific changes in cervical pre-cancer share similarities with changes in cervical screening cytology. [PDF]

J Natl Cancer Inst
Adcock R, Wheeler CM, Hunt WC, Torrez-Martinez NE, Robertson M, McDonald R, Joste NE, Stoler MH, de Koning MNC, Quint WGV, New Mexico HPV Pap Registry Steering Committee Members .   +10 more
europepmc   +1 more source