Results 251 to 260 of about 940,897 (342)

Multiscale mechanistic modelling of heterogeneity in cardiac sub‐cellular calcium handling accounting for variable t‐system density

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Illustration of spatial calcium dynamics (left panels) and the state cycle approximation (middle panel) that enables reduced simulation of spatially dependent dynamics without explicit description of space (right panels). The selected example here illustrates a spontaneous calcium wave, showing temporal snapshots of local calcium
Michael A Colman   +2 more
wiley   +1 more source

The role of group III/IV afferent feedback in the ventilatory, pressor and metabolic responses to exercise in normoxia and hypoxia

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Participants completed cycling exercise with (placebo) and without (25 µg intrathecal fentanyl) intact group III/IV muscle afferent feedback in three settings: normoxia, acute hypoxia and chronic hypoxia after 7–9 days of acclimatisation (∼3800 m). Blocking afferent feedback suppressed exercise hyperpnoea across all environments,
Elliott J. Jenkins   +23 more
wiley   +1 more source

Synchrony within Aβ mechanoreceptor subtypes governs signal propagation to primary somatosensory cortex

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend We used an optogenetic gain‐of‐function manipulation to investigate how sensory signals from two subtypes of Aβ low threshold mechanoreceptors (LTMRs) contribute to the cortical representation of touch. CatCh, a sensitive and fast channelrhodopsin variant, enables pulsed‐light generation of high‐frequency action potential trains ...
Wanyi Liu   +2 more
wiley   +1 more source

View Order With Arbitrary Center Echoes

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 5, Page 2127-2139, November 2026.
ABSTRACT Purpose To provide explicit, vendor‐independent view‐order constructions that enable selection of an arbitrary center echo in multi‐shot imaging, with a focus on RARE and MPRAGE. Methods Vendor‐independent view‐order methods were developed to assign echo and shot indices to a prescribed set of phase encodes, enabling explicit selection of the ...
Henric Rydén   +4 more
wiley   +1 more source

Enhanced Transmit Efficiency of a Loop Array Combined With Out‐of‐Phase Passive Dipoles for Thoracic Spinal Cord MRI at 7T

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 5, Page 2539-2552, November 2026.
ABSTRACT Purpose The design of radiofrequency (RF) coils tailored for the target anatomy is necessary to overcome the transmit field homogeneity and penetration issues at Ultra‐High‐Field (UHF). For the spinal cord, the optimal design has not yet been determined. This work intends to demonstrate the added value of a pair of passive dipoles placed under
Hugo Amat   +10 more
wiley   +1 more source

Hypothyroidism resulting from follicular‐compact thyroid carcinoma in a dog

open access: yesVeterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 13‐year‐old, spayed, female beagle, weighing 21 kg, was presented with a cervical nodule that had appeared about 15 days earlier. On palpation, a firm, slightly mobile mass measuring approximately 4 cm in diameter was detected in the thyroid region.
Júlio César Nascimento de Cerqueira Júnior   +4 more
wiley   +1 more source

The Homozygous p.(Arg215Ter) Variant in XRCC2 Is Associated With Atypical Fanconi Anemia Without Major Hematological Abnormalities in Childhood

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2331-2337, October 2026.
ABSTRACT Fanconi Anemia (FA) is the most frequent inherited bone marrow failure syndrome. A role for the XRCC2 gene in FA was suspected in 2012 and confirmed in 2016, but only two affected individuals have been described thus far, and no long‐term follow‐up is available.
Sabina Cenciarelli   +11 more
wiley   +1 more source

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