Results 51 to 60 of about 117,385 (313)

The effect of performing corrections on reported uterine cancer mortality data in the city of São Paulo

Brazilian Journal of Medical and Biological Research, 2006
Reports of uterine cancer deaths that do not specify the subsite of the tumor threaten the quality of the epidemiologic appraisal of corpus and cervix uteri cancer mortality.
J.L.F. Antunes, V. Wünsch-Filho
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Cervix Type and Cervical Cancer Classification System Using Deep Learning Techniques

Medical Devices: Evidence and Research, 2022
Lidiya Wubshet Habtemariam,1 Elbetel Taye Zewde,1,2 Gizeaddis Lamesgin Simegn1,2 1Biomedical Imaging Unit, School of Biomedical Engineering, Jimma Institute of Technology, Jimma University, Jimma, Ethiopia; 2AI and Biomedical Imaging Research unit, Jimma
Habtemariam LW, Zewde ET, Simegn GL
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Factores asociados al incumplimiento del despistaje oportuno con papanicolaou en la detección temprana del cáncer de cérvix en un centro poblado rural

Acta Médica Peruana, 2019
Objetivo: Determinar los factores asociados al incumplimiento del despistaje oportuno con Papanicolaou (PAP) en la detección temprana de cáncer de cérvix.
Antonio Aldave-Zamora, Moises Apolaya-Segura   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The HPV cellular transactivator Brn-3a can be used to predict cervical adenocarcinoma and squamous carcinoma precancer lesions in the developed and developing worlds

, 2009
The cellular transactivator Brn-3a has previously been shown to be expressed at elevated levels in the cervix of women with squamous cell carcinoma of the cervix (SCC) and to activate the expression of HPV E6 mRNA.
Ndisang, D., Ashfaq Khan, Sindos, M., Lorenzato, F., Khan, A., Latchman, David S., Singer, A., Felipe Lorenzato, David S. Latchman, Daniel Ndisang, Michael Sindos, Albert Singer   +11 more
core   +1 more source

Cancer-associated fibroblast activation protein in Appalachian women with uterine cervix cancer

Frontiers in Oncology
Introduction[212Pb]Pb-PSV-359 is a radiopharmaceutical utilizing an alpha particle-emitting radionuclide lead-212 (212Pb) and a fibroblast activation protein (FAPα)-targeted antagonist being assessed as anticancer treatment. Prior nuclear imaging studies
Denise Fabian, Morgan S. Levy, Dava W. Piecoro, Dana Napier, Rachel W. Miller, Charles A. Kunos   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source