Results 61 to 70 of about 117,385 (313)

Survival analysis of 1148 women diagnosed with breast cancer in Southern Iran [PDF]

, 2009
Background: while there has been much research regarding risk factors and prognostic factors for breast cancer in general, research specific to Iran is sparse.
Talei, Abdolrasoul, Rezaianzadeh, Abbas, Daniel Reidpath, Reidpath Daniel, Reidpath, D, Peacock, J, Hosseini, SV, Talei Abdolrasoul, Hosseini, Seyed Vahid, Hosseini, Seyed Vahid, Seyed Hosseini, Rezaianzadeh Abbas, Davood Mehrabani, Talei, A, Janet Peacock, Hoseini Seyed, Mehrabani, D, Mehrabani Davood, Rezaianzadeh, A, Peacock, Janet, Hosseini, S.V, Peacock Janet, Seyed Vahid Hosseini, Peacock, J.L, Mehrabani, Davood, Reidpath, Daniel, Abdolrasoul Talei, Reidpath, DD, Abbas Rezaianzadeh   +28 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The knowledge, Attitude, Practice and Perceived Barriers Towards Screening for Premalignant Cervical Lesions Among Women Aged 18years and Above, in Songea Urban, Ruvuma [PDF]

, 2011
Cervical cancer is the second most common cancer among women worldwide. About 83% of the cases occur in developing countries, representing 15% of female cancers.
John, James
core  

Radical Hysterectomy or Total Mesometrial Resection—Two Anatomical Concepts for Surgical Treatment of Cancer of the Uterine Cervix

, 2023
A radical hysterectomy is the standard method of surgical treatment for patients with early-stage cancer of the uterine cervix. It was first introduced more than 100 years ago.
Pavel Sorokin, Hakan Yalçın, Ilker Selçuk, Stoyan Kostov, Bruno Rezende   +4 more
core   +1 more source

Knowledge, attitudes and practice toward cervical cancer screening among Sikkimese nursing staff in India

Indian Journal of Medical and Paediatric Oncology, 2015
Objectives: To assess baseline knowledge of cancer cervix, screening and practice of Pap smear screening among Sikkimese staff nurses in India. Materials and Methods: Between April 2012 and February 2013, a predesigned, pretested, self -administered ...
Hafizur Rahman, Sumit Kar
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Isolated metastatic pancreatic adenocarcinoma to the uterine cervix: A case report

Gynecologic Oncology Reports, 2019
The uterine cervix is an uncommon site of metastatic cancer. Specifically, pancreatic adenocarcinoma metastatic to the cervix is an exceptionally rarely reported phenomenon.
Emily M. Hartsough, Britt K. Erickson, Anil Chauhan, Mahmoud A. Khalifa   +3 more
doaj   +1 more source

Changing the Prognosis of Metastatic Cervix Uteri Adenosquamous Carcinoma through a Multimodal Approach: A Case Report

Case Reports in Oncology, 2020
Adenocarcinoma and adenosquamous carcinoma (AS) are 2 rare histological types of cervix uteri cancer constituting almost 20% of all cervix cancers, leading to a lack in patient management guidelines.
Mihai Teodor Georgescu, Dragos Eugen Georgescu, Teodor Florin Georgescu, Luiza Georgia Serbanescu   +3 more
doaj   +1 more source