Results 141 to 150 of about 15,603 (268)

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

RioM‐1: A New Calcite Reference Material for U‐Pb LA‐ICP‐MS Geochronology

Geostandards and Geoanalytical Research, EarlyView.
Key Points RioM‐1 calcite was characterised for trace elements, U‐Pb geochronology, Sr and O isotopes using ID‐TIMS, LA‐ICP‐MS and SIMS. U‐Pb dates from ID‐TIMS and LA‐ICP‐MS across several independent laboratories returned identical results within uncertainty.
Marco Silva, Cristiano Lana, Ricardo Scholz, Ian Buick, Sandra Kamo, Nick M.W. Roberts, Axel Gerdes, Michael Wiedenbeck, Blair Schoene, Francisco E. Apen, Sean P. Gaynor   +10 more
wiley   +1 more source

A Cesium-134 Trap for Isotope Use

The Florida Entomologist, 1975
E. S. Del Fosse, H. L. Cromroy
openaire   +1 more source

New Magnetite Reference Material for SIMS δ18O Measurements and a Study of Precision and Accuracy Due to Crystal Orientation Effects

Geostandards and Geoanalytical Research, EarlyView.
Key Points A new magnetite reference material (PF21mt) is available for δ18O measurements by SIMS. Reproducibility of measurement results in two laboratories suggest orientation bias of ±2‰ (2s) at 20 keV. Repeatability improves to ±1‰ (2s) when using a 13 keV protocol, suggesting reduced orientation bias. In situ isotope ratio measurements provide the
Michelle Ulrich, Daniela Rubatto, Maria Rosa Scicchitano, Benita Putlitz, Thomas Bovay   +4 more
wiley   +1 more source

Salt glands in exo‐recretohalophytes: Development, physiological functions, and prospects for improving crop salt tolerance

Journal of Integrative Plant Biology, EarlyView.
This review examines salt glands in exo‐recretohalophytes, in which epidermal stem cells differentiate into unicellular, bicellular, or multicellular salt glands. Salt ions are transported to the leaves via the transpiration stream and enter salt glands through symplastic and apoplastic pathways. Finally, salt glands actively secrete salt ions from the
Limin Wang, Junyan Xie, Yiping Zou, Chunliang Yao, Hai Fan, Chenqi Shen, Wenyan Zhou, Jingran Qin, Xinke Zhang, Baoshan Wang, Jian Zhang, Guoliang Han   +11 more
wiley   +1 more source

Decoding Metamorphic Nanodiamonds Formation Through Their Internal Structures

Journal of Metamorphic Geology, EarlyView.
ABSTRACT Metamorphic diamonds offer insights into Earth's evolution, modulating the global carbon cycle through subduction into the mantle and exhumation. However, the formation and internal structure of minute diamonds remain poorly understood. Here, we study the internal structures of diamond‐bearing inclusions from the Eastern Alps using state‐of ...
Tim Sotelšek, Marian Janák, Sašo Šturm, Sorour Semsari Parapari, Nik Gračanin, Kristian Radan, Mehmet Ali Gülgün, Stanislava Milovská, Mirijam Vrabec   +8 more
wiley   +1 more source

Drelów, the 13th and latest meteorite fall in Poland—A typical L6 chondrite with shock veins

Meteoritics &Planetary Science, EarlyView.
Abstract On Tuesday, February 18, 2025, at 18:04:14 local time, residents of Poland observed a bright fireball registered by many Polish fireball stations belonging to the Skytinel Network established a few months before by Mateusz Żmija. Thus, the meteoroid's orbit, atmospheric trajectory, and the strewn field were calculated, and over 70 fragments ...
Addi Bischoff, Krzysztof Szopa, Jean‐Alix Barrat, Stig Bartel, Jasper Berndt, Tommaso Di Rocco, Dieter Heinlein, Stephan Klemme, Tomasz Krzykawski, Björn Lehnert, Agnieszka Mirek, Andreas Pack, Markus Patzek, Marie Pichotta, Maximilian P. Reitze, Stefan Ruchti, Philippe Schmitt‐Kopplin, Karl Wimmer, Mateusz Żmija   +18 more
wiley   +1 more source

B‐GATA factors are required for nitrogen‐responsive growth in Physcomitrium patens and Arabidopsis thaliana

New Phytologist, EarlyView.
Summary We hypothesized that B‐GATA family transcription factors have important roles in growth regulation in moss. We analyzed B‐GATA family transcription factor mutants from Physcomitrium patens and Arabidopsis thaliana to assess growth, gene expression, and cytokinin‐related processes under varying nitrogen conditions.
Dario Zappone, Peter Michael Schröder, Ivan Petřík, Xiao Dong, Rudi Schäufele, Korbinian Schneeberger, Ondřej Novák, Claus Schwechheimer   +7 more
wiley   +1 more source

Multi‐Omics Combined With Mitochondrial Feeding Assays Reveal a Novel Energy Metabolism Strategy for Floral Thermogenesis in Magnolia Driven by Synergistic Supply of Multiple Substrates

Plant Biotechnology Journal, EarlyView.
ABSTRACT The high demand for energy during floral thermogenesis drives the synergistic operation of multiple energy substrates for the rapid temperature rise and successful reproduction of flowers. However, how thermogenic plants precisely regulate substrate supply and metabolic pathways within a short time to support large‐scale energy and heat ...
Siqin Wang, Jiying Li, Zhang Wang, Miao Yu, Chang Liu, Dongye Liu, Ruohan Wang   +6 more
wiley   +1 more source