Results 151 to 160 of about 81,604 (317)

π‐Expanded Nitrogen‐Cation (N+)‐Doped Polycyclic Aromatic Hydrocarbons: A Review of Intramolecular Cyclization Routes to Benzo[c]Quinolizinium, Triazinium, Pyridoquinazolinium, and Pyridoquinoxalinium Frameworks

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 4, January 26, 2026.
This review surveys recent progress in the synthesis of extended aromatic quinolizinium derivatives via intramolecular SNAr and oxidative 6π‐electrocyclization. Conventional thermal approaches are discussed alongside emerging, sustainable activation methods such as electrosynthesis and photochemical processes.
Marine Labro   +2 more
wiley   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao   +2 more
wiley   +1 more source

Chloride Sensor Based on Silver Nanoparticles Coupled with a Fast‐Response MOSFET System

open access: yesAdvanced Sensor Research, Volume 5, Issue 1, January 2026.
A potentiometric sensor based on a MOSFET device (Metal‐Oxide‐Semiconductor Field‐Effect Transistor) and silver nanoparticles (AgNPs) was developed for chloride quantification, offering increased signals, fast response, and efficient data processing, which can be used for monitoring and diagnosis.
Ricardo Antonio Escalona‐Villalpando   +9 more
wiley   +1 more source

Distribution of CFTR gene mutations in cystic fibrosis patients from Estonia [PDF]

open access: bronze, 2000
M. Teder   +4 more
openalex   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino   +21 more
wiley   +1 more source

Pharmacogenomics in clinical practice: Biomarker information in Brazilian drug labels

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 109-118, January 2026.
This review examines the PGx annotations in package inserts (bulas in Brazilian Portuguese) approved by ANVISA, the Brazilian Health Regulatory Agency, for 19 gene–drug pairs with strong or moderate recommendations for initial dosing alteration in the CPIC (Clinical Pharmacogenetic Implementation Consortion) guidelines and PGx testing required or ...
Guilherme Suarez‐Kurtz
wiley   +1 more source

Quantitative Systems Toxicology Predicts Ivacaftor‐Induced Oxidative Stress Contributes to CFTR Modulator Hepatotoxicity

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 208-218, January 2026.
Cystic fibrosis (CF) is a chronic hereditary disease that affects tens of thousands of people worldwide. The introduction of CFTR modulator therapies such as elexacaftor/tezacaftor/ivacaftor (ETI) has significantly improved the quality of life of people with CF.
Alan Shi   +3 more
wiley   +1 more source

Single‐nucleus RNA sequencing reveals the distinct heterogeneity of primary pulmonary sarcomas (PPS) and pulmonary sarcomatoid carcinoma (PSC)

open access: yesClinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Single‐nucleus RNA sequencing (snRNA‐seq) maps the cellular diversity of pulmonary sarcomatoid carcinoma (PSC) and primary pulmonary sarcomas (PPS). AT2 cells, a major source of epithelial cells in PSC, underwent malignant transformation primarily through epithelial–mesenchymal transition, suggesting AT2 cells may serve as the origin of PSC.
Jianfei Zhu   +11 more
wiley   +1 more source

Correlation between Ivacaftor-induced CFTR Activation in Airway Epithelial Cells and Improved Lung Function: A Proof-of-Concept Study

open access: green, 2020
Jason S. Debley   +5 more
openalex   +2 more sources

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