Results 151 to 160 of about 5,299 (208)

Considerations for the use of inhaled antibiotics for Pseudomonas aeruginosa in people with cystic fibrosis receiving CFTR modulator therapy. [PDF]

BMJ Open Respir Res
Burgel PR, Ballmann M, Drevinek P, Heijerman H, Jung A, Mainz JG, Peckham D, Plant BJ, Schwarz C, Taccetti G, Smyth A.   +10 more
europepmc   +1 more source

Laboratory Tools to Predict CFTR Modulator Therapy Effectiveness and to Monitor Disease Severity in Cystic Fibrosis. [PDF]

J Pers Med
Bacalhau M, Camargo M, Lopes-Pacheco M.
europepmc   +1 more source

Qualitative study exploring the views and perceptions of parents/carers of young children with CF regarding the introduction of CFTR modulator therapy (The REVEAL study; PaRents pErspectiVEs of KAftrio in chiLdren aged 2-5). [PDF]

BMJ Open Respir Res
Davies SH, Wade F, Fogg H, Walsh A, Southern KW.   +4 more
europepmc   +1 more source

Changes in vitamins and trace elements after initiation of highly effective CFTR modulator therapy in children and adults with cystic fibrosis - a real-life insight. [PDF]

Mol Cell Pediatr
Fabricius D, Knieling T, Zurmuehl N, Makedon L, Freihorst J, Schmidt H, Bode S.   +6 more
europepmc   +1 more source

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Impact of interruption of CFTR modulator therapies

Journal of Cystic Fibrosis
Novel drug therapy targeting the defective cystic fibrosis transmembrane conductance regulator protein has the potential to significantly enhance the quality of life for numerous patients with cystic fibrosis. However, in some countries social insurance does not pay for modulators because these drugs are extremely expensive.
Ebru Yalcin, Didem Alboga
exaly   +3 more sources

The impact of CFTR modulators on bone health

Pediatric Pulmonology, 2022
We are hopeful that CTFR modulation does have a positive impact of bone health, but we have concerns about this study design being used to support the hypothesis.
Elizabeth, Clarke, Fiona, Moore, Andrew, Gallagher, Stephen, Thomson   +3 more
openaire   +2 more sources

CFTR is a modulator of airway inflammation

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2007
although it has been 17 years since the identification of the cystic fibrosis transmembrane ion receptor (CFTR) gene and protein, it remains enigmatic how abnormalities in CFTR can cause chronic and persistent pulmonary infection and inflammation that lead to bronchiectasis and end-stage ...
openaire   +2 more sources

WNK1 and WNK4 modulate CFTR activity

Biochemical and Biophysical Research Communications, 2007
The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-gated chloride channel. WNK kinases are widely expressed modulators of ion transport. WNK1 and WNK4, two WNK kinases that are mutated in familial hyperkalemic hypertension (FHHt), are co-expressed with CFTR in several organs, raising the possibility that WNK kinases might alter ...
Chao-Ling, Yang, Xuehong, Liu, Alex, Paliege, Xiaoman, Zhu, Sebastian, Bachmann, David C, Dawson, David H, Ellison   +6 more
openaire   +2 more sources

CFTR Modulators for the Gastroenterologist

Journal of Pediatric Gastroenterology and Nutrition, 2023
Sabina, Sabharwal, Sarah Shrager, Lusman
openaire   +2 more sources

CFTR Modulator Therapies for Cystic Fibrosis

Pediatric Allergy, Immunology, and Pulmonology, 2015
The cloning of cystic fibrosis transmembrane conductance regulator (CFTR) set into motion a cascade of discoveries that have helped to reveal the underlying pathophysiologic basis of cystic fibrosis (CF). This discovery and the knowledge that followed have also provided the opportunity to target this basic defect, with the hope of reversing or ...
Aaron T, Trimble, Scott H, Donaldson
openaire   +2 more sources