Results 291 to 300 of about 1,231,622 (330)

CFTR modulator therapy: transforming the landscape of clinical care in cystic fibrosis

The Lancet, 2023
J. Taylor-Cousar, Paul D Robinson, M. Shteinberg, Damian G. Downey   +3 more
semanticscholar   +1 more source

CFTR Modulators for the Gastroenterologist

Journal of Pediatric Gastroenterology and Nutrition, 2023
Sabina, Sabharwal, Sarah Shrager, Lusman
openaire   +2 more sources

Expanding CFTR Modulator Testing to Carriers of CFTR Variants

Annals of the American Thoracic Society, 2021
Preston E, Bratcher, Pamela L, Zeitlin
openaire   +2 more sources

CFTR modulates lung secretory cell proliferation and differentiation

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2000
We have permanently reversed the lethal phenotype in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR)-deficient (knockout) mouse after in utero gene therapy with an adenovirus containing the cftr gene. The gene transfer targeted somatic stem cells in the developing lung and intestine, and these epithelial surfaces demonstrated ...
J E, Larson, J B, Delcarpio, M M, Farberman, S L, Morrow, J C, Cohen   +4 more
openaire   +2 more sources

CFTR is a modulator of airway inflammation

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2007
although it has been 17 years since the identification of the cystic fibrosis transmembrane ion receptor (CFTR) gene and protein, it remains enigmatic how abnormalities in CFTR can cause chronic and persistent pulmonary infection and inflammation that lead to bronchiectasis and end-stage ...
openaire   +2 more sources

Understanding and addressing the needs of people with cystic fibrosis in the era of CFTR modulator therapy.

The Lancet Respiratory Medicine, 2023
K. B. Hisert, S. Birket, J. P. Clancy, Damian G. Downey, J. Engelhardt, Isabelle Fajac, Robert D Gray, M. Lachowicz-Scroggins, N. Mayer-Hamblett, Patrick Thibodeau, K. Tuggle, C. Wainwright, K. de Boeck   +12 more
semanticscholar   +1 more source

CFTR Modulator Therapies in Cystic Fibrosis

2017
Cystic fibrosis (CF), the most common life-shortening autosomal recessive disorder in Caucasians, results from mutations in the gene that encodes the cystic fibrosis transmembrane-conductance regulator (CFTR) protein. Nearly 2000 CFTR mutations have been identified as being associated with disease, with known effects of a given mutation on protein ...
David R. Spielberg, John P. Clancy, Christopher Siracusa   +2 more
openaire   +1 more source

A case report of CFTR modulator administration via carrier mother to treat meconium ileus in a F508del homozygous fetus.

Journal of Cystic Fibrosis, 2022
S. Szentpetery, K. Foil, S. Hendrix, S. Gray, C. Mingora, Barbara Head, Donna Johnson, P. Flume   +7 more
semanticscholar   +1 more source

Drug-drug interactions with CFTR modulator therapy in cystic fibrosis: Focus on Trikafta®/Kaftrio®.

Journal of Cystic Fibrosis, 2023
Debanjali Purkayastha, Kyla Agtarap, Kristy Wong, Onella Pereira, Jannie Co, S. Pakhalé, S. Kanji   +6 more
semanticscholar   +1 more source

CFTR-​Modulation im Kindesalter

Pädiatrie & Pädologie, 2022
openaire   +1 more source