Results 51 to 60 of about 1,459,532 (261)

The CFTR Amplifier Nesolicaftor Rescues TGF-β1 Inhibition of Modulator-Corrected F508del CFTR Function

, 2022
Highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators have led to dramatic improvements in lung function in many people with cystic fibrosis (PwCF).
Sireesha Yerrathota, Michael Kim, Matthias Salathe, Salathe, Matthias, Yerrathota, Sireesha, Nathalie Baumlin, Yoshida, Makoto, Silswal, Neerupma, Dennis, John, Baumlin, Nathalie, Charles Bengtson, Kim, Michael, Neerupma Silswal, John Dennis, Bengtson, Charles, Makoto Yoshida   +15 more
core   +1 more source

Of muscle modulation and the CFTR gate [PDF]

Journal of General Physiology, 2015
This month’s installment of Generally Physiological considers regulation of excitation–contraction coupling by PIP2 and the investigation of an appealing hypothesis for how a transporter might evolve into a channel.
openaire   +2 more sources

Effect of CFTR modulator therapy with elexacaftor/tezacaftor/ivacaftor on pulmonary ventilation derived by 3D phase-resolved functional lung MRI in cystic fibrosis patients

European Radiology, 2023
Objectives To investigate whether 3D phase-resolved functional lung (PREFUL)-MRI parameters are suitable to measure response to elexacaftor/tezacaftor/ivacaftor (ETI) therapy and their association with clinical outcomes in cystic fibrosis (CF) patients ...
F. Klimeš, A. Voskrebenzev, M. Gutberlet, M. Speth, R. Grimm, M. Dohna, G. Hansen, F. Wacker, D. Renz, A. Dittrich, J. Vogel-Claussen   +10 more
semanticscholar   +1 more source

Dual CFTR modulator therapy efficacy in the real world: lessons for the future

, 2022
Stringent analyses caution against drawing conclusions about the real-world efficacy of CFTR modulator therapy too early https://bit.ly ...
Chuang, Sandra Y., Anna-Maria Dittrich, Dittrich, Anna-Maria, Sandra Y. Chuang   +3 more
core   +1 more source

Chronic rhinosinusitis in patients with cystic fibrosis—Current management and new treatments

Laryngoscope Investigative Otolaryngology, 2020
Objectives The purpose of this article is to provide a state‐of‐the‐art review of the literature and summarize the latest publications on medical and surgical treatment of cystic fibrosis (CF) chronic rhinosinusitis (CRS), with an emphasis on describing ...
Brian Jake Johnson, Garret W. Choby, Erin K. O'Brien   +2 more
doaj   +1 more source

CFTR Modulates Orai1 Dynamics [PDF]

Biophysical Journal, 2011
Calcium signaling regulates many cellular processes and is upregulated in cystic fibrosis (CF) epithelial cells. Agonists stimulate Ca2+ release from ER stores and trigger the formation of a complex between the plasma membrane (PM) Ca2+ channel Orai1 and stromal interaction molecule 1 (STIM1), a primarily endoplasmic reticulum (ER) resident protein ...
AbuArish, Asmahan, Balghi, Haouaria, Arane, Tal, Wiseman, Paul, Hanrahan, John   +4 more
openaire   +1 more source

CF Fungal Disease in the Age of CFTR Modulators [PDF]

Mycopathologia, 2021
AbstractFungi are increasingly recognised to have a significant role in the progression of lung disease in Cystic fibrosis with Aspergillus fumigatus the most common fungus isolated during respiratory sampling. The emergence of novel CFTR modulators has, however, significantly changed the outlook of disease progression in CF.
Amelia Bercusson, George Jarvis, Anand Shah   +2 more
openaire   +3 more sources

Cystic fibrosis-related liver disease: clinical presentations, diagnostic and monitoring approaches in the era of CFTR modulator therapies.

Journal of Hepatology, 2021
Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian population. Cystic Fibrosis-related Liver Disease (CFLD) is defined by the pathogenesis related to the underlying CFTR defect in biliary epithelial cells.
Jérémy Dana, D. Debray, A. Beaufrère, S. Hillaire, M. Fabre, C. Reinhold, T. Baumert, L. Berteloot, V. Vilgrain   +8 more
semanticscholar   +1 more source

Cognitive Outcome After Deep Brain Stimulation for Refractory Obsessive–Compulsive Disorder: A Systematic Review

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Introduction Deep brain stimulation (DBS) is an effective treatment for refractory obsessive–compulsive disorder (OCD). Neuropsychological assessment contributes to DBS treatment in several ways: it monitors the cognitive safety of the treatment, identifies beneficial or detrimental cognitive side effects and it could aid to explain ...
Tim A. M. Bouwens van der Vlis, Annelien Duits, Mégan M. G. H. van de Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens   +7 more
wiley   +1 more source

A provider survey assessing fetal impact of CFTR modulator use in males with CF during assisted and unassisted reproduction and partner pregnancy.

Journal of Cystic Fibrosis, 2023
BACKGROUND Most males with cystic fibrosis (mwCF) are infertile but with CF transmembrane conductance regulator (CFTR) modulator-conferred benefits, more are utilizing assisted reproductive technologies (ART).
J. Taylor-Cousar, R. Janney, P. Middleton, Raksha Jain, Julia A. Nightingale, Natalie E. West, M. Shteinberg, D. Velez, T. Kazmerski   +8 more
semanticscholar   +1 more source