Results 181 to 190 of about 12,522 (293)

Greenness, Whiteness, and Blueness Assessment With a Novel and Fully Validated HPLC Method for Simultaneous Analysis of Lumacaftor and Ivacaftor in Sweat

International Journal of Analytical Chemistry, Volume 2026, Issue 1, 2026.
Sweat is an alternative biological fluid to plasma, urine, hair, and saliva, and it is promising for various pharmaceutical research types. Excessive sweating is one of the symptoms of cystic fibrosis, a hereditary disease. In this study, an easy, simple, applicable, and economical HPLC method was proposed for sweat analysis of the lumacaftor/ivacaftor
Serkan Levent, Abeer Elriş, Saniye Özcan, Nafiz Öncü Can, Deepali   +4 more
wiley   +1 more source

Treating Non-cystic Fibrosis Bronchiectasis with CFTR modulators: Early Case Reports [PDF]

Colin E Swenson, William R Hunt, Candela Manfredi, Diana Beltran, Jeong S Hong, Cynthia Chico, Joy Dangerfield, Elizabeth M Cox, Ashleigh Streby, Arlene Stecenko, Rebecca Kapolka, Eric J Sorscher   +11 more
openalex   +1 more source

From Pathophysiology to Treatment: Contemporary Approaches to CFRD in the Pediatric and Adolescent Population

Pediatric Diabetes, Volume 2026, Issue 1, 2026.
Cystic fibrosis‐related diabetes (CFRD) is the most prevalent nonrespiratory complication of cystic fibrosis (CF), with its prominence growing as survival rates improve due to advances in CFTR modulator therapies. Its prevalence increases with age, affecting nearly 50% of patients with CF (PwCF) over 30 years old.
Dogus Vuralli, Andrea Scaramuzza
wiley   +1 more source

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source

Isolation and long‐term culture of primary mouse cholangiocytes that retain biophysical properties and distinct Cl‐conductances: An initial study

Physiological Reports, Volume 14, Issue 2, January 2026.
Mouse cholangiocytes are isolated from bile ducts and cultured in conditioned medium containing ROCK inhibitor. Cells maintain expression of biliary markers & ion channel activity for >50 passages. Abstract Cultures of primary mouse bile duct epithelial cells are a valuable tool to study cholangiocyte secretion and bile formation.
Qin Li, Youxue Wang, Kristy Boggs, Charles Kresge, Kari Nejak‐Bowen   +4 more
wiley   +1 more source

P25 Managing adverse effects with cftr modulators [PDF]

A. Sareen
openalex   +1 more source

Advances in pancreatic cancer early diagnosis, prevention, and treatment: The past, the present, and the future

CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a dismal prognosis, largely because of late‐stage diagnosis and therapeutic resistance. PDAC incidence has been rising, with modifiable and non‐modifiable risk factors contributing to disease development.
Alessandro Mannucci, Ajay Goel
wiley   +1 more source

WS14.02 Cystic fibrosis personalised medicine; paediatric in vitro airway cell models to predict CFTR modulator patient outcomes [PDF]

, 2023
Laura K. Fawcett, Adam Jaffé, Shafagh A. Waters   +2 more
openalex   +1 more source

Improvement of lipid and lipoprotein profiles in children and adolescents with cystic fibrosis on CFTR modulator therapy [PDF]

, 2023
Tatiana Yuzyuk, Catherine M. McDonald, Lauren M. Zuromski, Irene De Biase, Lisa Johnson, Nicole Williams, S. Meihls, Fadi Asfour   +7 more
openalex   +1 more source

L467F;F508del Complex Allele in a Heterozygous State with CFTRdele2,3: What to Expect from CFTR Modulators? [PDF]

Int J Mol Sci
Kondratyeva E, Efremova A, Melyanovskaya Y, Krasnova M, Milovanov M, Shchagina O, Stepanova A, Voronkova A, Sherman V, Kutsev S, Goldshtein D.   +10 more
europepmc   +1 more source