Results 261 to 270 of about 12,522 (293)
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CFTR modulates lung secretory cell proliferation and differentiation
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2000We have permanently reversed the lethal phenotype in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR)-deficient (knockout) mouse after in utero gene therapy with an adenovirus containing the cftr gene. The gene transfer targeted somatic stem cells in the developing lung and intestine, and these epithelial surfaces demonstrated ...
J E, Larson +4 more
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CFTR is a modulator of airway inflammation
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2007although it has been 17 years since the identification of the cystic fibrosis transmembrane ion receptor (CFTR) gene and protein, it remains enigmatic how abnormalities in CFTR can cause chronic and persistent pulmonary infection and inflammation that lead to bronchiectasis and end-stage ...
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CFTR Modulator Therapies in Cystic Fibrosis
2017Cystic fibrosis (CF), the most common life-shortening autosomal recessive disorder in Caucasians, results from mutations in the gene that encodes the cystic fibrosis transmembrane-conductance regulator (CFTR) protein. Nearly 2000 CFTR mutations have been identified as being associated with disease, with known effects of a given mutation on protein ...
David R. Spielberg +2 more
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PULMONOLOGY: CFTR modulators for cystic fibrosis
Journal of the American Academy of Physician Assistants, 2013Erica, Bertoncini, Dawn, Colomb-Lippa
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Simplifying CFTR modulation therapy in cystic fibrosis
Archives of Disease in Childhood, 2023openaire +2 more sources
CFTR function, pathology and pharmacology at single-molecule resolution
Nature, 2023Jesper Levring +2 more
exaly
Molecular structures reveal synergistic rescue of Δ508 CFTR by Trikafta modulators
Science, 2022, Jue Chen
exaly
CFTR Modulator Therapy For N1303K Mutations
B103. HOT TOPICS IN CYSTIC FIBROSIS, BRONCHIECTASIS, AND BREATHLESSNESS, 2023P. Barletta +3 more
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