Results 131 to 140 of about 80,761 (294)

Super‐Enhancer Formation in Scirrhous Gastric CAFs, and the Presence of a Stromal Field in Non‐Cancerous Tissues

Cancer Science, EarlyView.
While CAFs are produced as a result of education by cancer cells in non‐scirrhous gastric cancer, normal fibroblasts of scirrhous gastric cancer patients are already pre‐conditioned, forming a stromal field for scirrhous gastric cancer. ABSTRACT Scirrhous gastric cancer has aggressive clinical courses and is characterized by dominating cancer ...
Yoshimi Yasukawa, Naoko Hattori, Yu‐Yu Liu, Masayuki Tobo, Genki Yamagishi, Takahiro Irie, Shigeki Sekine, Tohru Kiyono, Satoshi Yamashita, Yukinori Yamagata, Takaki Yoshikawa, Yasuyuki Seto, Toshikazu Ushijima   +12 more
wiley   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Chronic thermal stress affects growth, liver morphology and molecular responses but allows recovery at optimal temperature in juvenile zebrafish (Danio rerio)

Journal of Fish Biology, EarlyView.
Abstract Climate‐driven aquatic heatwaves pose an increasing threat to fish populations by inducing prolonged thermal stress. However, the resilience of teleosts to chronic heat exposure and their capacity for recovery remains poorly understood. This study investigated the effects of chronic high‐temperature exposure on juvenile zebrafish (Danio rerio).
Monique Adzijovski, Aaron G. Schultz, Jemma Bergfeld, Luis O. B. Afonso   +3 more
wiley   +1 more source

St John's Wort (Hypericum perforatum) Oil on Immune Response, Growth Performance and Bacterial Resistance Against Lactococcus garvieae Pathogen in Rainbow Trout (Oncorhynchus mykiss)

Journal of Fish Diseases, EarlyView.
ABSTRACT In this study, we investigated the immunomodulatory effects of St. John's Wort (Hypericum perforatum) oil on the growth performance, immune responses and resistance against Lactococcus garvieae in rainbow trout (Oncorhynchus mykiss). The plant oil was incorporated into feeds at concentrations of 1, 3, and 5 g kg−1, designated as K1, K3, and K5,
Soner Bilen, Mustafa Karga, Osman Nezih Kenanoğlu, Ertuğrul Terzi   +3 more
wiley   +1 more source

The transcription factors TaABI4 and TaNAC‐A1 fine‐tune TaCYP94‐A1 transcription to modulate seed dormancy in wheat

Journal of Integrative Plant Biology, EarlyView.
A module involving the transcription factors TaABI4 and TaNAC‐A1, and the cytochrome P450 TaCYP94‐A1 precisely regulates seed dormancy levels through plant hormone crosstalk, providing targets for improving resistance to pre‐harvest sprouting in wheat.
Litian Zhang, Yuhui Fang, Yunfei Zhou, Xianlai Nie, Shujun Cao, Wei Gao, Yu Wang, Lianghua Dai, Lin Ye, Jie Lu, Chuanxi Ma, Cheng Chang, Haiping Zhang   +12 more
wiley   +1 more source

Multidrug resistance of bacterial pathogens in canine pyometra

Journal of Small Animal Practice, EarlyView.
Objectives To characterise multidrug antimicrobial resistance and pathogenicity profiles of bacteria isolated from different anatomical sites in bitches with pyometra, emphasising their clinical relevance for diagnosis and therapeutic decision‐making in small animal practice.
M. G. M. Camozzi, S. B. Waller, E. C. Castelhano, A. L. S. Neves, B. R. Arrais, J. F. N. Pinto, B. G. Alves, C. N. Moreira   +7 more
wiley   +1 more source

The vesicle trafficking R‐SNARE VAMP714 connects auxin responses, ROS and ion homeostasis in Arabidopsis under salt stress

New Phytologist, EarlyView.
Network of VAMP714‐dependent interactions during salt stress. Summary Plant responses to salt stress include an altered root architecture mediated by ion imbalances, reactive oxygen species (ROS) accumulation, and altered hormonal responses. Auxin is implicated in these processes.
Jialei Sun, Julien Agneessens, Jennifer F. Topping, Keith Lindsey   +3 more
wiley   +1 more source

Cytokinin downregulates Photosystem II photochemistry during prolonged darkness in a phytochrome B‐dependent manner

New Phytologist, EarlyView.
Cytokinin–phyB signaling modulates PSII photochemistry during prolonged darkness. Summary Cytokinins (CKs) delay dark‐induced senescence, but how they tune photosynthetic function in darkness remains unclear. We investigated the effects of classical aromatic CK benzylaminopurine and CK‐derived compound 1‐(2‐methoxyethyl)‐3‐(1,2,3‐thiadiazol‐5‐yl)urea ...
Veronika Kábrtová, Zuzana Kučerová, Ivo Chamrád, René Lenobel, Pavel Roudnický, Jan Skalák, Martin Hudeček, Filip Zavadil Kokáš, Marek Rác, Tereza Vánská, Jaroslav Nisler, Jan Hejátko, Miroslav Strnad, Martina Špundová, Ondřej Plíhal   +14 more
wiley   +1 more source

OsbHLH064, an IVb bHLH Transcription Factor, Regulates Iron Homeostasis and Enhances Grain Fe Accumulation in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Iron (Fe) is an essential micronutrient for plant growth and development. The maintenance of Fe homeostasis relies on sophisticated regulatory networks where bHLH transcription factors play a key role. However, how these factors coordinate to regulate this vital process is not fully understood.
Fei Gao, Zhikai Zhu, Kaixin Xue, Zijing Fu, Jitong Yue, Na Zhang, Hongli Zhou, Yaqin Deng, Jing Zhou, Liuhui Kuang, Tao Yan, Lin Li, Christian Dubos, Dezhi Wu   +13 more
wiley   +1 more source

New Integrative Vectors Increase Agrobacterium rhizogenes Transformation and Help Characterise Roles for Soybean GmTML Gene Family Members

Plant, Cell &Environment, EarlyView.
ABSTRACT Hairy‐root transformation is widely used to generate transgenic plant roots for genetic functional characterisation studies. However, transformation efficiency can be limited, largely due to the use of binary vectors. Here, we report on the development of novel integrative vectors that significantly increase the transformation efficiency of ...
Huanan Su, Mengbai Zhang, Estelle B. Grundy, Brett J. Ferguson   +3 more
wiley   +1 more source