Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 468-484, September 2026.ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri +13 more
wiley +1 more source
Butenolide Exerts Antifouling Effects on the Bryozoan <i>Bugula neritina</i> through Activating NO/cGMP Signaling Pathway. [PDF]
Integr Org BiolLiu HL +9 more
europepmc +1 more source
A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations
Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1726-1732, August 2026.ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley +1 more source
The NPR1 agonist antibody XXB750 in heart failure: a phase 2 randomized trial. [PDF]
Nat MedSolomon SD +11 more
europepmc +1 more source
Brain and Behavior, Volume 16, Issue 8, August 2026.scRNA‐seq atlas of the depressed mouse colon reveals that expansion of disease‐specific cCF1 and CTF stromal subsets disrupts epithelial homeostasis via enhanced TGF‐ß and suppressed WNT/ß‐catenin signaling, impairing stem cell function, differentiation, and intestinal barrier integrity.
Xiao‐Song Xu +8 more
wiley +1 more source
Effect of two-dimensional spatial confinement on platelet mechanics. [PDF]
Biophys Rep (N Y)Balmes A, Gidlund V, Schäffer TE.
europepmc +1 more source
CLRN1 Variants in Müller Cells Cause Mitochondrial Dysfunction in USH3A Retinal Organoids
CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.We generated retinal organoids from a patient with USH3A and performed single‐cell RNA sequencing. CLRN1 was specifically expressed in Müller cells, where its variants led to mitochondrial dysfunction and photoreceptor degeneration. ABSTRACT Background Usher syndrome 3A (USH3A), caused by mutations in the CLRN1 gene, leads to retinitis pigmentosa and ...
Rui Zhang +19 more
wiley +1 more source
Spermidine stimulates hypocrellin A biosynthesis through nitric oxide signaling in Shiraia sp. S9. [PDF]
Bioresour BioprocessZheng LP +4 more
europepmc +1 more source
Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases
Comprehensive Physiology, Volume 16, Issue 4, August 2026.Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal +2 more
wiley +1 more source
Cyclic guanosine monophosphate-protein kinase G signaling attenuates aortic valve calcification through ULK1-mediated autophagy. [PDF]
Signal Transduct Target TherWang Y +11 more
europepmc +1 more source