Results 161 to 170 of about 77,168 (243)

Automated Multienzyme Digestion Workflows for Confident Characterization of Challenging Posttranslational Modifications in Therapeutic Antibodies by LC–MS/MS

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale Non‐reduced trypsin digestion of therapeutic antibodies can generate large disulfide‐linked peptide complexes that exhibit poor chromatographic and mass spectrometric performance. This limits the confident characterization of posttranslational modifications (PTMs) in specific antibody regions, such as the heavy‐chain constant region ...
Nanna Sofie Eskesen, Yann Leblanc, Justine Lempereur, Martin Ørgaard, Elizabeta Madzharova, Trine M. Sloth, Simon Krabbe, Alexandra K. Rebak, Magali André, Pernille F. Jensen, Dan B. Kristensen   +10 more
wiley   +1 more source

Synergistic modulation of cAMP and cGMP rescues hemin-induced plasma membrane fragmentation. [PDF]

J Biol Chem
Laspa Z, Rohlfing AK, Fischer M, Kollotzek F, Castor T, Borst O, Sowa PW, Sigle M, Harm T, Gawaz MP.   +9 more
europepmc   +1 more source

Persisting Region‐Specific Microglia Activation and Synaptic Imbalance During Remission in a DSS‐Induced Colitis Model

Glia, Volume 74, Issue 11, November 2026.
Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton, Luis E. Villafuerte, Alejandra P. Garza, Nina Lindemann, Elisa Wider‐Eberspächer, Dunja Bruder, Ildiko R. Dunay   +6 more
wiley   +1 more source

Pharmacological activation of cGMP signaling promotes astrocyte remodeling and enrichment of perivascular GLUT1 in the murine retina. [PDF]

Front Cell Neurosci
Clark KL, Mecca S, Almaoui E, Bossardet OL, Holden JM, Calkins DJ, Wareham LK.   +6 more
europepmc   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, Volume 183, Issue 21, Page 6422-6443, November 2026.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Investigation of the putative mechanism by which <i>Ferula sinkiangensis</i> leaves alleviate functional Dyspepsia-like symptoms in rats via modulation of the NO/cGMP/PKG signaling pathway. [PDF]

Front Pharmacol
Xia X, Wang D, Liu J, Liu Y, Zhang H, Jianaer B, Fan F, Zhao S.   +7 more
europepmc   +1 more source

MdPHYB2‐MdPIF1 Module Regulates Transcription Factors to Mediate Light‐Dependent ALA‐Induced Apple Anthocyanin Biosynthesis

Plant, Cell &Environment, Volume 49, Issue 11, Page 7808-7824, November 2026.
ABSTRACT Light is a primary environmental signal that induces plant anthocyanin accumulation. The plant growth regulator 5‐aminolevulinic acid (ALA) has also been proven to effectively promote anthocyanin accumulation in apple. However, the underlying regulatory mechanisms remain unknown.
Liuzi Zhang, Yuyan An, Jianting Zhang, Liangju Wang   +3 more
wiley   +1 more source

Therapeutic Modulation of Nitric Oxide Pathways to Address Insulin Resistance in Cardiovascular-Kidney-Metabolic Syndrome. [PDF]

Int J Mol Sci
Ceteraș LM, Brata VD, Dobrotă I, Borbei R, Clim M, Alexescu TG, Milaciu MV, Perne MG, Gerdanovics CA, Cozma A, Orășan OH.   +10 more
europepmc   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

<i>Mucuna pruriens</i> var. <i>pruriens</i> Ethanolic Seed Extract Enhances Erectile Function-Related Mechanisms: Integrated In Vitro and In Vivo Evidence. [PDF]

Biology (Basel)
Intatham S, Kunnaja P, Yimsoo T, Na Takuathung M, Khonsung P, Jaijoy K, Chansakaow S, Puangpradab R, Sireeratawong S.   +8 more
europepmc   +1 more source