Results 181 to 190 of about 56,515 (255)

Global Use of Casein Glycomacropeptide Protein Substitutes for Phenylketonuria (PKU): Health Professional Perspectives. [PDF]

Nutrients
Evans S, Singh R, Ahring K, Ashmore C, Daly A, Ford S, Gama MI, Giżewska M, Hill M, Ilgaz F, Jackson R, Newby C, Pinto A, Tosi M, Nas OY, Zuvadelli J, MacDonald A.   +16 more
europepmc   +1 more source

Elevated LncRNA LINC00966 Suppresses PDE2A to Impair Sperm Motility in Asthenozoospermia

FASEB BioAdvances, Volume 8, Issue 8, August 2026.
This study identifies LINC00966 as an upregulated lncRNA in asthenozoospermia associated with reduced sperm quality. Linc00966 suppresses Pde2a, disrupts cGMP signaling, and promotes oxidative stress, thereby impairing spermatogenic cell viability and migration.
Bingrou Guo, Junyi Ke, Hanran Mai, Ting Zhang, Zhaojin Lu, Zilin Zheng, Jieyi Luo, Yifan Zhang, Mei Yan, Shuo Yang, Yanxia Qu, Fan Jiang, Xiaoping Liu, Hao Chen, Liandong Zuo   +14 more
wiley   +1 more source

Mesenchymal Stromal Cell Rejuvenation Strategies to Enhance Clinical Translation in Cell Therapy

Aging Cell, Volume 25, Issue 8, August 2026.
MSC rejuvenation strategies and functional outcomes. Aging‐associated alterations in MSCs, including increased IL‐6/IL‐8 secretion, ROS accumulation, epigenetic drift, and mitochondrial dysfunction, impair stemness. Rejuvenation approaches, epigenetic modulation (VPA, AZAc, OSKM, TERT), metabolic interventions (resveratrol, calcitriol, NMD, asprosin ...
Astrid Sodomaco, Irene Bernardi, Aretha Rambaldi, Pierluigi Lombardi, Maura Rossi, Francesca Paris, Lucia Manzoli, Stefano Ratti, Francesco Alviano   +8 more
wiley   +1 more source

An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channel. [PDF]

Commun Biol
Costa F, Ng LCT, Chow SS, Van Petegem F, Accili EA.   +4 more
europepmc   +1 more source

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries

British Journal of Pharmacology, Volume 183, Issue 16, Page 5018-5032, August 2026.
Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan, JinHeng Lin, Milind Khashu, Christopher J. Garland, Kim A. Dora   +4 more
wiley   +1 more source

[Petroleum ether fraction of <i>Myrica nana</i> roots relieves spasmodic abdominal pain in mice by inhibiting intestinal smooth muscle spasm]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Yang S, Chen W, Chen X, Tian K, Xiong Y, Sun J, Huang L, Huang X, Wang Z.   +8 more
europepmc   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A. [PDF]

Phytother Res
Chen L, Zhou X, You Y, Chen J, Peng B, Deng Y, Ji S, Yang Y, Chen X, Liu H, Yang S, Kwan HY, Jin W, Zhang L, Wang Y, Zhao X, Liu Y.   +16 more
europepmc   +1 more source

The Evolving Landscape of Pulmonary Hypertension Treatment: From Vasodilation to Disease Modification

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Pulmonary hypertension (PH) is a complex disorder associated with significant morbidity and mortality. PH is characterized by an elevated pulmonary vascular load, leading to right ventricular dysfunction and remodeling, with right heart failure and premature death if left untreated.
Surya Ayalasomayajula, Ednan K. Bajwa, Alexandra G. Cornell, Maria Jose Loureiro, Samuel S. Kim, Julia Richmond DiBello, Eric Sterner, Richard Chen, Islam R. Younis   +8 more
wiley   +1 more source

Comprehensive multiomics analyses identify guanylate cyclase activator 1A as a photoreceptor-specific target in a murine model of oxygen-induced retinopathy. [PDF]

J Transl Med
Yang Q, Wang J, Wu T, Liu S, Zhang Y, Wang X, Zhang W, Rong H, Wu M, Zhao Y, Cao Y, Zhang M, Shen H, Zhang Y.   +13 more
europepmc   +1 more source