Synthesis of USP Grade [2,3,7‐13C3]‐Nicotinamide for Human Pharmacokinetic Studies
Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 12, October 2026.We prepared a 17.8‐g quantity of [2,3,7‐13C3]‐nicotinamide in five synthetic steps, with a 42% overall yield, and purified it to > 99% homogeneity, meeting USP standards for oral pharmaceutical dosing. This material is intended for tracking the movement and metabolism of nicotinamide through the human body.
Bruce G. Szczepankiewicz +10 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 10, October 2026.ABSTRACT Contrast‐induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine ...
Mustafa Begenc Tascanov +10 more
wiley +1 more source
The Therapeutic Efficacy of Drugs Targeting the NO-sGC-cGMP Pathway in Treatment of Patients With Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review. [PDF]
Pulm CircAlqarni AA +9 more
europepmc +1 more source
MedComm, Volume 7, Issue 10, October 2026.This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng +4 more
wiley +1 more source
Etiology-oriented rodent models of erectile dysfunction: a narrative review of categorization, modeling strategies, and translational applications. [PDF]
Transl Androl UrolYin F +8 more
europepmc +1 more source
Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments
MedComm, Volume 7, Issue 10, October 2026.Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma +9 more
wiley +1 more source
Applying Cognitive Load Theory to Improve Instructional Efficiency and Learner Experience in Current Good Manufacturing Practices Training for Pharmacists. [PDF]
Pharmacy (Basel)Wilson RD, Arefin P, Sansgiry SS.
europepmc +1 more source
Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies
MedComm, Volume 7, Issue 10, October 2026.Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng +7 more
wiley +1 more source
Redox regulation of PDE6 and cGMP signaling in diabetic retinal neurodegeneration. [PDF]
Biochem Biophys RepPerez-Martinez CJ +9 more
europepmc +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.ABSTRACT Incretin effect helps in regulating glucose homeostasis and maintaining glycaemic control within the human body. This effect is achieved by the two naturally occurring incretin hormones: glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1).
Nora H. J. Alharbi
wiley +1 more source