Incremental effects of vericiguat added to sacubitril/valsartan in heart failure with nonpreserved ejection fraction: a real-world study. [PDF]
Kinoshita H +4 more
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SGK1 signaling: an important modulator of CFTR function and early immune response in mouse intestine. [PDF]
Muiler C, Santos A, Ameen NA.
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Unresolved mechanisms: a hypothesized spatial regulation of myosin light chain phosphorylation within the walls of resistance arteries. [PDF]
Sun Z, Hill MA.
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Protective Effect of Paeoniae Radix Alba Carbonisata on Hepatic Amyloidosis by Regulating Calcium Homeostasis. [PDF]
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Redefining the role of the transfusion medicine physician in the era of advanced cellular therapies
Transfusion, Volume 66, Issue 8, Page 1645-1656, August 2026.
Eric A. Gehrie, Kevin J. Land
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Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase
Cellular Signalling, 2002The structure of cyclic GMP (cGMP)-binding (cGB), cGMP specific phosphodiesterase (PDE5) comprises several domains. We have used RT-PCR methods to clone the noncatalytic cGB domains of PDE5 from human colon cancer cell RNA and constructed glutathione-S-transferase (GST) fusion proteins to express and study the domains.
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A primer for measuring cGMP signaling and cGMP-mediated vascular relaxation
Nitric Oxide, 2021Soluble guanylyl cyclase (sGC, also called GC1) is the main receptor for nitric oxide (NO) that catalyzes the production of the second messenger molecule, 3'5' cyclic guanosine monophosphate (cGMP) leading to vasorelaxation, and inhibition of leukocyte recruitment and platelet aggregation.
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Allosteric Activation of cGMP-Specific, cGMP-Binding Phosphodiesterase (PDE5) by cGMP
Biochemistry, 2002The effects of cGMP binding on the catalytic activity of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) are unclear because cGMP interacts with both allosteric and catalytic sites specifically. We studied the effects of cGMP on the hydrolysis of a fluorescent substrate analogue, 2'-O-anthraniloyl cGMP, by PDE5 partially purified from rat ...
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