Results 211 to 220 of about 56,515 (255)
Some of the next articles are maybe not open access.
2009
Cyclic guanosine 3', 5'-monophosphate (cGMP) plays an integral role in the control of vascular function. Generated from guanylate cyclases in response to the endogenous ligands, nitric oxide (NO) and natriuretic peptides (NPs), cGMP influences a number of vascular cell types and regulates vasomotor tone, endothelial permeability, cell growth and ...
Barbara, Kemp-Harper +1 more
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Cyclic guanosine 3', 5'-monophosphate (cGMP) plays an integral role in the control of vascular function. Generated from guanylate cyclases in response to the endogenous ligands, nitric oxide (NO) and natriuretic peptides (NPs), cGMP influences a number of vascular cell types and regulates vasomotor tone, endothelial permeability, cell growth and ...
Barbara, Kemp-Harper +1 more
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Biochemistry, 2008
We describe here a novel sensor for cGMP based on the GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase 5 (PDE5) using bioluminescence resonance energy transfer (BRET). The wild type GAFa domain, capable of binding cGMP with high affinity, and a mutant (GAFa F163A) unable to bind cGMP were cloned as fusions between GFP and Rluc for BRET ...
Biswas, Kabir Hassan +2 more
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We describe here a novel sensor for cGMP based on the GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase 5 (PDE5) using bioluminescence resonance energy transfer (BRET). The wild type GAFa domain, capable of binding cGMP with high affinity, and a mutant (GAFa F163A) unable to bind cGMP were cloned as fusions between GFP and Rluc for BRET ...
Biswas, Kabir Hassan +2 more
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Regulation of metabolism by cGMP
Pharmacology & Therapeutics, 2013The second messenger cyclic guanosine monophosphate (cGMP) mediates the physiological effects of nitric oxide and natriuretic peptides in a broad spectrum of tissues and cells. So far, the major focus of research on cGMP lay on the cardiovascular system.
Alexander Pfeifer, Ana Kilic
exaly +3 more sources
Modulation of synaptic function by cGMP and cGMP-gated cation channels
Neurochemistry International, 2004Cyclic nucleotide-gated cation channels have been studied intensively in the primary sensory neurons of the visual and olfactory systems. Using both anatomical and physiological methods we have shown that they have a much more widespread distribution in the nervous system.
Colin J, Barnstable +2 more
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In Vivo NO/cGMP Signalling in the Hippocampus
Neurochemical Research, 2001In the hippocampus of freely-moving rats, basal extracellular levels of cGMP are inhibited by L-NARG or ODQ whereas they are increased by NO donors or phosphodiesterase inhibitors. Activation of NMDA receptors also augments cGMP dialysate levels in a MK-801 and L-NARG sensitive manner, an effect dramatically diminished during ageing.
FEDELE, ERNESTO +2 more
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Molecular and Cellular Biochemistry, 2009
Production of cGMP in bacteria has been studied since the early 1970s. From the beginning on it proved to be a challenging topic. In Escherichia coli the cGMP levels were two orders of magnitude lower than the corresponding cAMP levels. Furthermore, no specific cGMP receptor protein was identified in the bacterium and a physiological role of cGMP in ...
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Production of cGMP in bacteria has been studied since the early 1970s. From the beginning on it proved to be a challenging topic. In Escherichia coli the cGMP levels were two orders of magnitude lower than the corresponding cAMP levels. Furthermore, no specific cGMP receptor protein was identified in the bacterium and a physiological role of cGMP in ...
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2018
NO wird in Endothelzellen synthetisiert und aktiviert in glatten Muskelzellen die sGC, die den second messenger cGMP produziert. Die wichtigste Funktion von cGMP ist die Relaxation glatter Muskelzellen. cGMP wird uber die PDE5 abgebaut. Der NO-Donator GTN aktiviert die sGC und relaxiert Muskelzellen.
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NO wird in Endothelzellen synthetisiert und aktiviert in glatten Muskelzellen die sGC, die den second messenger cGMP produziert. Die wichtigste Funktion von cGMP ist die Relaxation glatter Muskelzellen. cGMP wird uber die PDE5 abgebaut. Der NO-Donator GTN aktiviert die sGC und relaxiert Muskelzellen.
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cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases
1995Publisher Summary The signaling pathways by which nitric oxide (NO) affects cell function, are by no means limited to the stimulation of guanylate cyclase. Concentrations of NO that activate guanylate cyclase may also have other effects on cells.
T M, Lincoln +4 more
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Cytotherapy, 1999
Over the past 20 years cell processing has changed. What an under statement! The types of cells processed, the complexity of the procedures, the addition of gene therapy and ex vivo cell expansion protocols together challenge the laboratory scientist.
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Over the past 20 years cell processing has changed. What an under statement! The types of cells processed, the complexity of the procedures, the addition of gene therapy and ex vivo cell expansion protocols together challenge the laboratory scientist.
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cGMP and cGMP-Dependent Protein Kinase in Platelets and Blood Cells
2009Platelets are specialized adhesive cells that play a key role in normal and pathological hemostasis through their ability to rapidly adhere to subendothelial matrix proteins (platelet adhesion) and to other activated platelets (platelet aggregation). NO plays a crucial role in preventing platelet adhesion and aggregation.
Ulrich, Walter, Stepan, Gambaryan
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