Results 221 to 230 of about 56,515 (255)
Some of the next articles are maybe not open access.
Insights into cGMP signalling derived from cGMP kinase knockout mice
Frontiers in Bioscience - Landmark, 2005cGMP signalling plays an important physiological role in diverse organs including the vasculature, the GI-tract and the nervous system. Furthermore, cGMP-elevating substances such as glyceryl trinitrate are important drugs used in cardiovascular diseases.
Franz Hofmann +2 more
exaly +3 more sources
Science's STKE, 2000
Cyclic nucleotides are important second messengers. Jedlitschky et al . expressed the human multidrug resistance protein 5 (MDR5) in hamster fibroblasts and showed that these cells exhibit an enhanced high-affinity ATP-dependent transport of cyclic nucleotides into inside-out membrane vesicles.
openaire +2 more sources
Cyclic nucleotides are important second messengers. Jedlitschky et al . expressed the human multidrug resistance protein 5 (MDR5) in hamster fibroblasts and showed that these cells exhibit an enhanced high-affinity ATP-dependent transport of cyclic nucleotides into inside-out membrane vesicles.
openaire +2 more sources
Nitric Oxide, 2018
The intracellular messenger molecule cGMP has an established function in the regulation of numerous physiological events. Yet for the identification of further biological cGMP-mediated functions, precise information whether a cGMP response exists in a certain cell type or tissue is mandatory. In this review, the techniques to measure cGMP i.e.
Michael, Russwurm, Doris, Koesling
openaire +2 more sources
The intracellular messenger molecule cGMP has an established function in the regulation of numerous physiological events. Yet for the identification of further biological cGMP-mediated functions, precise information whether a cGMP response exists in a certain cell type or tissue is mandatory. In this review, the techniques to measure cGMP i.e.
Michael, Russwurm, Doris, Koesling
openaire +2 more sources
Molecular Pharmacology, 2010
cGMP-specific phosphodiesterase (PDE5) has become a target for drug development for the treatment of a number of physiological dysfunctions, affected by changes in the cGMP/cGMP-dependent protein kinase (PKG) signaling pathway. PDE5 has two highly homologous regulatory domains, GAF-A and GAF-B.
Irina G, Rybalkina +2 more
openaire +2 more sources
cGMP-specific phosphodiesterase (PDE5) has become a target for drug development for the treatment of a number of physiological dysfunctions, affected by changes in the cGMP/cGMP-dependent protein kinase (PKG) signaling pathway. PDE5 has two highly homologous regulatory domains, GAF-A and GAF-B.
Irina G, Rybalkina +2 more
openaire +2 more sources
Nitric oxide synthase, cGMP, and NO‐mediated cGMP production in the olfactory bulb of the rat
The Journal of Comparative Neurology, 1996High levels of nitric oxide synthase and cyclic 3',5'-guanosine monophosphate (cGMP) in the olfactory bulb suggest that nitric oxide, acting as a diffusible intercellular messenger molecule inducing increased synthesis of cGMP, plays an important role in olfaction.
D A, Hopkins +3 more
openaire +2 more sources
TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death
Cell, 2022Jijie Chai, Dongli Yu, Bin Wu
exaly