Results 241 to 250 of about 70,973 (282)
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Modulation of synaptic function by cGMP and cGMP-gated cation channels
Neurochemistry International, 2004Cyclic nucleotide-gated cation channels have been studied intensively in the primary sensory neurons of the visual and olfactory systems. Using both anatomical and physiological methods we have shown that they have a much more widespread distribution in the nervous system.
Colin J, Barnstable +2 more
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In Vivo NO/cGMP Signalling in the Hippocampus
Neurochemical Research, 2001In the hippocampus of freely-moving rats, basal extracellular levels of cGMP are inhibited by L-NARG or ODQ whereas they are increased by NO donors or phosphodiesterase inhibitors. Activation of NMDA receptors also augments cGMP dialysate levels in a MK-801 and L-NARG sensitive manner, an effect dramatically diminished during ageing.
FEDELE, ERNESTO +2 more
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Molecular and Cellular Biochemistry, 2009
Production of cGMP in bacteria has been studied since the early 1970s. From the beginning on it proved to be a challenging topic. In Escherichia coli the cGMP levels were two orders of magnitude lower than the corresponding cAMP levels. Furthermore, no specific cGMP receptor protein was identified in the bacterium and a physiological role of cGMP in ...
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Production of cGMP in bacteria has been studied since the early 1970s. From the beginning on it proved to be a challenging topic. In Escherichia coli the cGMP levels were two orders of magnitude lower than the corresponding cAMP levels. Furthermore, no specific cGMP receptor protein was identified in the bacterium and a physiological role of cGMP in ...
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cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases
1995Publisher Summary The signaling pathways by which nitric oxide (NO) affects cell function, are by no means limited to the stimulation of guanylate cyclase. Concentrations of NO that activate guanylate cyclase may also have other effects on cells.
T M, Lincoln +4 more
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2018
NO wird in Endothelzellen synthetisiert und aktiviert in glatten Muskelzellen die sGC, die den second messenger cGMP produziert. Die wichtigste Funktion von cGMP ist die Relaxation glatter Muskelzellen. cGMP wird uber die PDE5 abgebaut. Der NO-Donator GTN aktiviert die sGC und relaxiert Muskelzellen.
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NO wird in Endothelzellen synthetisiert und aktiviert in glatten Muskelzellen die sGC, die den second messenger cGMP produziert. Die wichtigste Funktion von cGMP ist die Relaxation glatter Muskelzellen. cGMP wird uber die PDE5 abgebaut. Der NO-Donator GTN aktiviert die sGC und relaxiert Muskelzellen.
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Cytotherapy, 1999
Over the past 20 years cell processing has changed. What an under statement! The types of cells processed, the complexity of the procedures, the addition of gene therapy and ex vivo cell expansion protocols together challenge the laboratory scientist.
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Over the past 20 years cell processing has changed. What an under statement! The types of cells processed, the complexity of the procedures, the addition of gene therapy and ex vivo cell expansion protocols together challenge the laboratory scientist.
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cGMP and cGMP-Dependent Protein Kinase in Platelets and Blood Cells
2009Platelets are specialized adhesive cells that play a key role in normal and pathological hemostasis through their ability to rapidly adhere to subendothelial matrix proteins (platelet adhesion) and to other activated platelets (platelet aggregation). NO plays a crucial role in preventing platelet adhesion and aggregation.
Ulrich, Walter, Stepan, Gambaryan
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Science's STKE, 2000
Cyclic nucleotides are important second messengers. Jedlitschky et al . expressed the human multidrug resistance protein 5 (MDR5) in hamster fibroblasts and showed that these cells exhibit an enhanced high-affinity ATP-dependent transport of cyclic nucleotides into inside-out membrane vesicles.
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Cyclic nucleotides are important second messengers. Jedlitschky et al . expressed the human multidrug resistance protein 5 (MDR5) in hamster fibroblasts and showed that these cells exhibit an enhanced high-affinity ATP-dependent transport of cyclic nucleotides into inside-out membrane vesicles.
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Nitric Oxide, 2018
The intracellular messenger molecule cGMP has an established function in the regulation of numerous physiological events. Yet for the identification of further biological cGMP-mediated functions, precise information whether a cGMP response exists in a certain cell type or tissue is mandatory. In this review, the techniques to measure cGMP i.e.
Michael, Russwurm, Doris, Koesling
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The intracellular messenger molecule cGMP has an established function in the regulation of numerous physiological events. Yet for the identification of further biological cGMP-mediated functions, precise information whether a cGMP response exists in a certain cell type or tissue is mandatory. In this review, the techniques to measure cGMP i.e.
Michael, Russwurm, Doris, Koesling
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Molecular Pharmacology, 2010
cGMP-specific phosphodiesterase (PDE5) has become a target for drug development for the treatment of a number of physiological dysfunctions, affected by changes in the cGMP/cGMP-dependent protein kinase (PKG) signaling pathway. PDE5 has two highly homologous regulatory domains, GAF-A and GAF-B.
Irina G, Rybalkina +2 more
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cGMP-specific phosphodiesterase (PDE5) has become a target for drug development for the treatment of a number of physiological dysfunctions, affected by changes in the cGMP/cGMP-dependent protein kinase (PKG) signaling pathway. PDE5 has two highly homologous regulatory domains, GAF-A and GAF-B.
Irina G, Rybalkina +2 more
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