Results 261 to 270 of about 43,468 (306)
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Cephalalgia, 2021
Introduction and objective Monoclonal antibodies targeting the calcitonin gene-related peptide pathway (anti-CGRP mAbs) have shown promising efficacy in randomised clinical trials for the prevention of episodic and chronic migraine, but no head-to-head ...
Konstantina Drellia +4 more
semanticscholar +1 more source
Introduction and objective Monoclonal antibodies targeting the calcitonin gene-related peptide pathway (anti-CGRP mAbs) have shown promising efficacy in randomised clinical trials for the prevention of episodic and chronic migraine, but no head-to-head ...
Konstantina Drellia +4 more
semanticscholar +1 more source
CGRP receptors: beyond the CGRP1–CGRP2 subdivision?
Trends in Pharmacological Sciences, 2001In a recent TiPS article 1xThe molecular pharmacology of CGRP and related peptide receptor subtypes. Juaneda, C. et al. Trends Pharmacol. Sci. 2000; 21: 432–438Abstract | Full Text | Full Text PDF | PubMed | Scopus (131)See all References1, Juaneda and colleagues reviewed the molecular pharmacology of calcitonin gene-related peptide (CGRP) and related ...
D, Poyner, I, Marshall
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CGRP antagonists: unravelling the role of CGRP in migraine
Trends in Pharmacological Sciences, 2007Migraine is a complex, debilitating neurovascular disorder. Although knowledge on the main molecular players is still incomplete, recent preclinical and clinical findings indicate that there is a clear correlation between migraine-associated headache and the release of the neuropeptide calcitonin gene-related peptide (CGRP). BIBN4096 was the first CGRP
Henri, Doods +3 more
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Pain pharmacology in migraine: focus on CGRP and CGRP receptors
Neurological Sciences, 2007Over the last 100 years, the discovery of new analgesics has been a complex and difficult task. However, remarkable progress in the identification of novel molecular targets relevant for pain medicines has been reported. Here we will focus on the neuropeptide calcitonin generelated peptide (CGRP) and its receptors (CGRP-R) because of their role in ...
BENEMEI, SILVIA +3 more
openaire +3 more sources
Journal of Medicinal Chemistry, 2020
The pivotal role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology was identified over 30 years ago, but the successful clinical development of targeted therapies has only recently been realized.
G. Dubowchik +2 more
semanticscholar +1 more source
The pivotal role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology was identified over 30 years ago, but the successful clinical development of targeted therapies has only recently been realized.
G. Dubowchik +2 more
semanticscholar +1 more source
Headache: The Journal of Head and Face Pain, 2017
The calcitonin gene‐related peptide (CGRP) neuropeptide system is an important but still evolving target for migraine. A fundamental consideration for all of the current drugs in clinical trials and for ongoing development in this area is the identity, expression pattern, and function of CGRP receptors because this knowledge ...
Debbie L. Hay, Christopher S. Walker
openaire +2 more sources
The calcitonin gene‐related peptide (CGRP) neuropeptide system is an important but still evolving target for migraine. A fundamental consideration for all of the current drugs in clinical trials and for ongoing development in this area is the identity, expression pattern, and function of CGRP receptors because this knowledge ...
Debbie L. Hay, Christopher S. Walker
openaire +2 more sources
Headache Currents, 2004
Neuronal Expression and Regulation of CGRP Promoter Activity Following Viral Gene Transfer into Cultured Trigeminal Ganglia Neurons We examined the regulation of calcitonin gene‐related peptide (CGRP) promoter activity in primary cultures of rat trigeminal ganglia neurons.
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Neuronal Expression and Regulation of CGRP Promoter Activity Following Viral Gene Transfer into Cultured Trigeminal Ganglia Neurons We examined the regulation of calcitonin gene‐related peptide (CGRP) promoter activity in primary cultures of rat trigeminal ganglia neurons.
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2018
Calcitonin gene-related peptide (CGRP) was discovered over about 35 years ago through molecular biological techniques. Its activity as a vasodilator and the proposal that it was involved in pain processing were then soon established. Today, we are in the interesting situation of having the approval for the clinical use of antagonists and antibodies ...
Arkless, Kate +2 more
openaire +3 more sources
Calcitonin gene-related peptide (CGRP) was discovered over about 35 years ago through molecular biological techniques. Its activity as a vasodilator and the proposal that it was involved in pain processing were then soon established. Today, we are in the interesting situation of having the approval for the clinical use of antagonists and antibodies ...
Arkless, Kate +2 more
openaire +3 more sources
Distribution of CGRP and CGRP receptor components in the rat brain
Cephalalgia, 2017Background Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies.
Warfvinge, Karin, Edvinsson, Lars
openaire +3 more sources
Headache, 2020
The monoclonal antibodies against calcitonin gene‐related peptide (CGRP) or its receptor are new antimigraine drugs from which many patients already benefit.
Katrine Falkenberg +2 more
semanticscholar +1 more source
The monoclonal antibodies against calcitonin gene‐related peptide (CGRP) or its receptor are new antimigraine drugs from which many patients already benefit.
Katrine Falkenberg +2 more
semanticscholar +1 more source