Safety and efficacy of calcitonin gene-related peptide antagonists for cluster headache: a systematic review and meta-analysis [PDF]
BMC NeurologyBackground Calcitonin gene-related peptide is an emerging therapeutic target in cluster headache, yet evidence on the preventive efficacy and safety of calcitonin gene-related peptide antagonists remains limited.
Ro’ya Khanfar +2 more
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The Calcitonin/Calcitonin Gene-Related Peptide Family in Invertebrate Deuterostomes [PDF]
Frontiers in Endocrinology, 2018 Calcitonin (CT)/CT gene-related peptide (CGRP) family peptides (CT/CGRP family peptides) including CT, CGRP, adrenomedullin, amylin, and CT receptor-stimulating peptide have been identified from various vertebrates and perform a variety of important ...
Toshio Sekiguchi
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Heat hyperalgesia and mechanical hypersensitivity induced by calcitonin gene-related peptide in a mouse model of neurofibromatosis. [PDF]
PLoS ONE, 2014 This study examined whether mice with a deficiency of neurofibromin, a Ras GTPase activating protein, exhibit a nociceptive phenotype and probed a possible contribution by calcitonin gene-related peptide.
Stephanie White +3 more
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Calcitonin gene-related peptide causes migraine aura
The Journal of Headache and Pain, 2023 Background Although the involvement of calcitonin gene-related peptide (CGRP) in migraines is well-established, its specific role in investigating the aura phase, which often precedes the headache, remains largely unexplored. This study aims to instigate
Haidar M. Al-Khazali +8 more
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Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin [PDF]
Biochemical Journal, 1991 Near-u.v. and far-u.v. c.d. spectra of human alpha-calcitonin-gene-related peptide (h alpha CGRP), analogues and fragments of CGRP and amylin were recorded in aqueous solution and in trifluoroethanol (TFE)/water mixtures. All peptides contained significant amounts of alpha-helix in aqueous solution, and this amount increased on adding TFE.
J A, Hubbard +5 more
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Improved osteoarthritis during erenumab treatment for migraine: a case report
Case Reports in Neurology, 2023 Antibodies blocking the calcitonin gene-related peptide have revolutionized episodic and chronic migraine treatment. However, their applicability to non-cephalic pain conditions, such as osteoarthritis is yet unknown.
Frederik Thal Jantzen +3 more
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Correlation between CGRP Levels and the Neuropathic and Inflammatory Component of Postoperative Pain [PDF]
Folia Medica, 2020 Introduction: In surgical procedures, tissue damage results in the release of a number of bioactive substances. Calcitonin gene-related peptide (CGRP) is a peptide released from sensory nerves, which determines its role in pain sensation.
Deyan Neychev +5 more
doaj +3 more sources
Calcitonin Gene-Related Peptide in Charcot Foot Neuroarthropathy
Foot & Ankle Orthopaedics, 2022 Category: Basic Sciences/Biologics; Diabetes Introduction/Purpose: Charcot neuroarthropathy (CNA) is a destructive joint condition secondary to neuropathic deficiency.
Yi Guo +5 more
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The Journal of Headache and Pain, 2019 Background and aim Monoclonal antibodies acting on the calcitonin gene-related peptide or on its receptor are new drugs to prevent migraine. Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor ...
Simona Sacco +6 more
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Molecular Pain, 2016 Although calcitonin gene-related peptide is a recognized pain transducer, the expression of calcitonin gene-related peptide in primary afferents may be differentially affected following different types of nerve injury. Here, we examined whether different
Yu Zou PhD +6 more
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