The Calcitonin/Calcitonin Gene-Related Peptide Family in Invertebrate Deuterostomes [PDF]
Frontiers in Endocrinology, 2018 Calcitonin (CT)/CT gene-related peptide (CGRP) family peptides (CT/CGRP family peptides) including CT, CGRP, adrenomedullin, amylin, and CT receptor-stimulating peptide have been identified from various vertebrates and perform a variety of important ...
Toshio Sekiguchi
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Safety and efficacy of calcitonin gene-related peptide antagonists for cluster headache: a systematic review and meta-analysis [PDF]
BMC NeurologyBackground Calcitonin gene-related peptide is an emerging therapeutic target in cluster headache, yet evidence on the preventive efficacy and safety of calcitonin gene-related peptide antagonists remains limited.
Ro’ya Khanfar +2 more
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Research Progress in Calcitonin Gene-Related Peptide and Bone Repair
Biomolecules, 2023 Calcitonin gene-related peptide (CGRP) has 37 amino acids. Initially, CGRP had vasodilatory and nociceptive effects. As research progressed, evidence revealed that the peripheral nervous system is closely associated with bone metabolism, osteogenesis ...
Qichang Wang +6 more
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Heat hyperalgesia and mechanical hypersensitivity induced by calcitonin gene-related peptide in a mouse model of neurofibromatosis. [PDF]
PLoS ONE, 2014 This study examined whether mice with a deficiency of neurofibromin, a Ras GTPase activating protein, exhibit a nociceptive phenotype and probed a possible contribution by calcitonin gene-related peptide.
Stephanie White +3 more
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Calcitonin gene-related peptide causes migraine aura
The Journal of Headache and Pain, 2023 Background Although the involvement of calcitonin gene-related peptide (CGRP) in migraines is well-established, its specific role in investigating the aura phase, which often precedes the headache, remains largely unexplored. This study aims to instigate
Haidar M. Al-Khazali +8 more
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Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin [PDF]
Biochemical Journal, 1991 Near-u.v. and far-u.v. c.d. spectra of human alpha-calcitonin-gene-related peptide (h alpha CGRP), analogues and fragments of CGRP and amylin were recorded in aqueous solution and in trifluoroethanol (TFE)/water mixtures. All peptides contained significant amounts of alpha-helix in aqueous solution, and this amount increased on adding TFE.
J A, Hubbard +5 more
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Improved osteoarthritis during erenumab treatment for migraine: a case report
Case Reports in Neurology, 2023 Antibodies blocking the calcitonin gene-related peptide have revolutionized episodic and chronic migraine treatment. However, their applicability to non-cephalic pain conditions, such as osteoarthritis is yet unknown.
Frederik Thal Jantzen +3 more
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Correlation between CGRP Levels and the Neuropathic and Inflammatory Component of Postoperative Pain [PDF]
Folia Medica, 2020 Introduction: In surgical procedures, tissue damage results in the release of a number of bioactive substances. Calcitonin gene-related peptide (CGRP) is a peptide released from sensory nerves, which determines its role in pain sensation.
Deyan Neychev +5 more
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Calcitonin Gene-Related Peptide in Charcot Foot Neuroarthropathy
Foot & Ankle Orthopaedics, 2022 Category: Basic Sciences/Biologics; Diabetes Introduction/Purpose: Charcot neuroarthropathy (CNA) is a destructive joint condition secondary to neuropathic deficiency.
Yi Guo +5 more
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The Journal of Headache and Pain, 2019 Background and aim Monoclonal antibodies acting on the calcitonin gene-related peptide or on its receptor are new drugs to prevent migraine. Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor ...
Simona Sacco +6 more
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