Results 21 to 30 of about 11,435,493 (279)

Calcitonin gene–related peptide in migraine: from pathophysiology to treatment

Neurología (English Edition), 2022
Introduction: It has been observed in recent years that levels of such molecules as calcitonin gene–related peptide (CGRP) and, to a lesser extent, the pituitary adenylate cyclase–activating peptide are elevated during migraine attacks and in chronic ...
S. Santos-Lasaosa, R. Belvís, M.L. Cuadrado, S. Díaz-Insa, A. Gago-Veiga, A.L. Guerrero-Peral, M. Huerta, P. Irimia, J.M. Láinez, G. Latorre, R. Leira, J. Pascual, J. Porta-Etessam, M. Sánchez del Río, J. Viguera, P. Pozo-Rosich   +15 more
doaj   +1 more source

Calcitonin gene-related peptide and menopause

Journal of Mid-life Health, 2010
The review summarizes recent findings with respect to pathophysiological role of calcitonin gene-related peptide (CGRP), in postmenopausal symptoms and diseases, which has opened horizons in understanding pathophysiology of menopause in a better way.
Sharma, Sudhaa, Mahajan, Annil, Tandon, Vishal R.   +2 more
openaire   +2 more sources

Calcitonin Gene-Related Peptide (CGRP) and Cluster Headache

Brain Sciences, 2020
Cluster headache (CH) is a severe primary headache with a prevalence of 1/1000 individuals, and a predominance in men. Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ...
Andrea Carmine Belin, Caroline Ran, Lars Edvinsson   +2 more
doaj   +1 more source

Exercise alleviates hypoalgesia and increases the level of calcitonin gene-related peptide in the dorsal horn of the spinal cord of diabetic rats

Clinics, 2012
OBJECTIVE: The aim of this study was to evaluate the effects of treadmill training on nociceptive sensitivity and immunoreactivity to calcitonin gene-related peptide in the dorsal horn of the spinal cord of diabetic rats.
Patrícia Severo do Nascimento, Gisele Agustini Lovatel, Jocemar Ilha, Léder L. Xavier, Beatriz D'Agord Schaan, Matilde Achaval   +5 more
doaj   +1 more source

Magnesium-based implants: Beyond fixators

Journal of Orthopaedic Translation, 2017
The mystery behind magnesium-induced bone formation is revealed by linking the neuropeptide(s) from sensory nerves with the osteogenic differentiation of stem cells in the periosteum.
Xiaodan Chen
doaj   +1 more source

How to integrate monoclonal antibodies targeting the calcitonin gene-related peptide or its receptor in daily clinical practice

The Journal of Headache and Pain, 2019
Background Migraine is a major public health issue associated with significant morbidity, considerable negative impact on quality of life, and significant socioeconomic burden.
Cindy Tiseo, Raffaele Ornello, Francesca Pistoia, Simona Sacco   +3 more
doaj   +1 more source

Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine

Molecular Pain, 2016
Background On trigeminal ganglion neurons, pain-sensing P2X3 receptors are constitutively inhibited by brain natriuretic peptide via its natriuretic peptide receptor-A. This inhibition is associated with increased P2X3 serine phosphorylation and receptor
Anna Marchenkova PhD, Sandra Vilotti PhD, Niels Ntamati MS, Arn MJM van den Maagdenberg PhD, Andrea Nistri MD   +4 more
doaj   +1 more source

Calcitonin gene-related peptide is potential therapeutic target of osteoporosis

Heliyon, 2022
Osteoporosis is a skeletal disorder characterised by the decrease of bone mineral density and is becoming prevalent with the entry of an ageing era.
Hua Wu, Xue-qin Lin, Yu Long, Jing Wang
doaj   +1 more source

Voluntary Forelimbs Exercise Reduces Immobilization-Induced Mechanical Hyperalgesia in the Rat Hind Paw

Pain Research and Management, 2021
Voluntary exercise is sufficient to protect against neuropathic pain. However, it is unclear whether voluntary exercise reduces immobilization-induced hyperalgesia. We examined the effect of voluntary forelimb exercise on immobilized-induced hyperalgesia
Kumiko Ishikawa, Satoshi Oga, Kyo Goto, Junya Sakamoto, Ryo Sasaki, Yuichiro Honda, Hideki Kataoka, Minoru Okita   +7 more
doaj   +1 more source

Calcitonin gene related peptide stimulates differentiation of neonatal rat myogenic cultures

, 1993
The effect of the nerve derived peptide, calcitonin gene related peptide (CGRP) on myoblast fusion/differentiation was studied in rat myogenic cell cultures, using creatine kinase activity as an index of fusion.
Noble, B.S., McMillan, D.N., Maltin, C.A.   +2 more
core   +3 more sources