Results 21 to 30 of about 13,600,961 (272)

Calcitonin gene-related peptide and menopause

Journal of Mid-life Health, 2010
The review summarizes recent findings with respect to pathophysiological role of calcitonin gene-related peptide (CGRP), in postmenopausal symptoms and diseases, which has opened horizons in understanding pathophysiology of menopause in a better way.
Sharma, Sudhaa, Mahajan, Annil, Tandon, Vishal R.   +2 more
openaire   +2 more sources

Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors

Frontiers in Molecular Biosciences, 2021
Class B1 G protein-coupled receptors (GPCRs) are important targets for many diseases, including cancer, diabetes, and heart disease. All the approved drugs for this receptor family are peptides that mimic the endogenous activating hormones.
Giuseppe Deganutti, Silvia Atanasio, Roxana-Maria Rujan, Patrick M. Sexton, Patrick M. Sexton, Denise Wootten, Denise Wootten, Christopher A. Reynolds   +7 more
doaj   +1 more source

Calcitonin Gene-Related Peptide (CGRP) and Cluster Headache

Brain Sciences, 2020
Cluster headache (CH) is a severe primary headache with a prevalence of 1/1000 individuals, and a predominance in men. Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ...
Andrea Carmine Belin, Caroline Ran, Lars Edvinsson   +2 more
doaj   +1 more source

Calcitonin gene–related peptide in migraine: from pathophysiology to treatment

Neurología (English Edition), 2022
Introduction: It has been observed in recent years that levels of such molecules as calcitonin gene–related peptide (CGRP) and, to a lesser extent, the pituitary adenylate cyclase–activating peptide are elevated during migraine attacks and in chronic ...
S. Santos-Lasaosa, R. Belvís, M.L. Cuadrado, S. Díaz-Insa, A. Gago-Veiga, A.L. Guerrero-Peral, M. Huerta, P. Irimia, J.M. Láinez, G. Latorre, R. Leira, J. Pascual, J. Porta-Etessam, M. Sánchez del Río, J. Viguera, P. Pozo-Rosich   +15 more
doaj   +1 more source

Calcitonin gene–related peptide inhibits angiotensin II–mediated vasoconstriction in human radial arteries: Role of the Kir channel

, 2008
The radial artery is increasingly used for coronary artery bypass grafts, but its potential for spasm increases postoperative risk. Alpha-calcitonin gene–related peptide is a potent antihypertensive peptide.
Hare, David L, Buxton, Brian F, Ye, Bei, Wookey, Peter J, Zulli, Anthony   +4 more
core   +5 more sources

Exercise alleviates hypoalgesia and increases the level of calcitonin gene-related peptide in the dorsal horn of the spinal cord of diabetic rats

Clinics, 2012
OBJECTIVE: The aim of this study was to evaluate the effects of treadmill training on nociceptive sensitivity and immunoreactivity to calcitonin gene-related peptide in the dorsal horn of the spinal cord of diabetic rats.
Patrícia Severo do Nascimento, Gisele Agustini Lovatel, Jocemar Ilha, Léder L. Xavier, Beatriz D'Agord Schaan, Matilde Achaval   +5 more
doaj   +1 more source

Magnesium-based implants: Beyond fixators

Journal of Orthopaedic Translation, 2017
The mystery behind magnesium-induced bone formation is revealed by linking the neuropeptide(s) from sensory nerves with the osteogenic differentiation of stem cells in the periosteum.
Xiaodan Chen
doaj   +1 more source

How to integrate monoclonal antibodies targeting the calcitonin gene-related peptide or its receptor in daily clinical practice

The Journal of Headache and Pain, 2019
Background Migraine is a major public health issue associated with significant morbidity, considerable negative impact on quality of life, and significant socioeconomic burden.
Cindy Tiseo, Raffaele Ornello, Francesca Pistoia, Simona Sacco   +3 more
doaj   +1 more source

Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine

Molecular Pain, 2016
Background On trigeminal ganglion neurons, pain-sensing P2X3 receptors are constitutively inhibited by brain natriuretic peptide via its natriuretic peptide receptor-A. This inhibition is associated with increased P2X3 serine phosphorylation and receptor
Anna Marchenkova PhD, Sandra Vilotti PhD, Niels Ntamati MS, Arn MJM van den Maagdenberg PhD, Andrea Nistri MD   +4 more
doaj   +1 more source

Calcitonin-gene related peptide and disease activity in cluster headache [PDF]

, 2019
Objective: To investigate the role of calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide in cluster headache, we measured these vasoactive peptides interictally and ...
Jensen, Rigmor H., Jørgensen, Niklas Rye, Vollesen, Anne Luise H, Beske, Rasmus P., Snoer, Agneta, Vollesen, Anne Luise H., Beske, Rasmus P, Martinussen, Torben, Hoffmann, Jan; id_orcid, Jensen, Rigmor H, Ashina, Messoud, Fahrenkrug, Jan, Guo, Song, Hoffmann, Jan   +13 more
core   +1 more source