Results 21 to 30 of about 36,287 (271)

European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention

The Journal of Headache and Pain, 2019
Background and aim Monoclonal antibodies acting on the calcitonin gene-related peptide or on its receptor are new drugs to prevent migraine. Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor ...
Simona Sacco, Lars Bendtsen, Messoud Ashina, Uwe Reuter, Gisela Terwindt, Dimos-Dimitrios Mitsikostas, Paolo Martelletti   +6 more
doaj   +1 more source

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]

, 2011
Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Beat Müller, Tanja Radimerski, Ralph Peterli, Ulrich Keller, Christ-Crain, Mirjam, Daniel M. Frey, Timper, Katharina, Frey, Daniel M., Mirjam Christ-Crain, Jean Grisouard, Häring, Andreas, Zulewski, Henryk, Keller, Ulrich, Grisouard, Jean, Katharina Timper, Henryk Zulewski, Radimerski, Tanja, Müller, Beat, Kaethi Dembinski, Dembinski, Kaethi, Andreas Häring, Peterli, Ralph   +21 more
core   +1 more source

Distinct calcitonin gene-related peptide expression pattern in primary afferents contribute to different neuropathic symptoms following chronic constriction or crush injuries to the rat sciatic nerve

Molecular Pain, 2016
Although calcitonin gene-related peptide is a recognized pain transducer, the expression of calcitonin gene-related peptide in primary afferents may be differentially affected following different types of nerve injury. Here, we examined whether different
Yu Zou PhD, Fangting Xu PhD, Zhaohui Tang MD, Tao Zhong PhD, Jiawei Cao MD, Qulian Guo PhD, Changsheng Huang MD   +6 more
doaj   +1 more source

Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors

Frontiers in Molecular Biosciences, 2021
Class B1 G protein-coupled receptors (GPCRs) are important targets for many diseases, including cancer, diabetes, and heart disease. All the approved drugs for this receptor family are peptides that mimic the endogenous activating hormones.
Giuseppe Deganutti, Silvia Atanasio, Roxana-Maria Rujan, Patrick M. Sexton, Patrick M. Sexton, Denise Wootten, Denise Wootten, Christopher A. Reynolds   +7 more
doaj   +1 more source

Phospholipase C gamma mediates endogenous brain-derived neurotrophic factor-regulated calcitonin gene-related peptide expression in colitis-induced visceral pain

Molecular Pain, 2016
Background Visceral hypersensitivity is a complex pathophysiological paradigm with unclear mechanisms. Primary afferent neuronal plasticity marked by alterations in neuroactive compounds such as calcitonin gene-related peptide is suggested to underlie ...
Fiza Hashmi MS, Miao Liu PhD, Shanwei Shen MS, Li-Ya Qiao PhD   +3 more
doaj   +1 more source

Calcitonin gene–related peptide in migraine: from pathophysiology to treatment

Neurología (English Edition), 2022
Introduction: It has been observed in recent years that levels of such molecules as calcitonin gene–related peptide (CGRP) and, to a lesser extent, the pituitary adenylate cyclase–activating peptide are elevated during migraine attacks and in chronic ...
S. Santos-Lasaosa, R. Belvís, M.L. Cuadrado, S. Díaz-Insa, A. Gago-Veiga, A.L. Guerrero-Peral, M. Huerta, P. Irimia, J.M. Láinez, G. Latorre, R. Leira, J. Pascual, J. Porta-Etessam, M. Sánchez del Río, J. Viguera, P. Pozo-Rosich   +15 more
doaj   +1 more source

Calcitonin gene-related peptide and menopause

Journal of Mid-life Health, 2010
The review summarizes recent findings with respect to pathophysiological role of calcitonin gene-related peptide (CGRP), in postmenopausal symptoms and diseases, which has opened horizons in understanding pathophysiology of menopause in a better way.
Sharma, Sudhaa, Mahajan, Annil, Tandon, Vishal R.   +2 more
openaire   +2 more sources

Calcitonin receptor-like receptor is expressed on gastrointestinal immune cells [PDF]

, 2002
Background/Aims: Pharmacological and morphological studies suggest that the gut mucosal immune system and local neuropeptide-containing neurones interact.
Göke, B., Haberberger, R., Knauer, J., McGregor, G. P., Hagner, S., Voigt, K.   +5 more
core   +1 more source

Calcitonin Gene-Related Peptide (CGRP) and Cluster Headache

Brain Sciences, 2020
Cluster headache (CH) is a severe primary headache with a prevalence of 1/1000 individuals, and a predominance in men. Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ...
Andrea Carmine Belin, Caroline Ran, Lars Edvinsson   +2 more
doaj   +1 more source

Exercise alleviates hypoalgesia and increases the level of calcitonin gene-related peptide in the dorsal horn of the spinal cord of diabetic rats

Clinics, 2012
OBJECTIVE: The aim of this study was to evaluate the effects of treadmill training on nociceptive sensitivity and immunoreactivity to calcitonin gene-related peptide in the dorsal horn of the spinal cord of diabetic rats.
Patrícia Severo do Nascimento, Gisele Agustini Lovatel, Jocemar Ilha, Léder L. Xavier, Beatriz D'Agord Schaan, Matilde Achaval   +5 more
doaj   +1 more source