Results 1 to 10 of about 43,027 (269)

CGRP Induces Differential Regulation of Cytokines from Satellite Glial Cells in Trigeminal Ganglia and Orofacial Nociception

International Journal of Molecular Sciences, 2019
Neuron-glia interactions contribute to pain initiation and sustainment. Intra-ganglionic (IG) secretion of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) modulates pain transmission through neuron-glia signaling, contributing to ...
Shaista Afroz, R. Arakaki, Takuma Iwasa, M. Oshima, Maki Hosoki, Miho Inoue, O. Baba, Y. Okayama, Y. Matsuka   +8 more
semanticscholar   +1 more source

Encoding of danger by parabrachial CGRP neurons

Nature, 2018
Animals must respond to various threats to survive. Neurons that express calcitonin gene-related peptide in the parabrachial nucleus (CGRPPBN neurons) relay sensory signals that contribute to satiation and pain-induced fear behaviour, but it is unclear ...
C. Campos, Anna J. Bowen, C. Roman, R. Palmiter   +3 more
semanticscholar   +1 more source

Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking

The Journal of Headache and Pain, 2019
Background Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches.
Raffi Manoukian, Hong Sun, Silke Miller, Di Shi, Brian Chan, Cen Xu   +5 more
doaj   +1 more source

Health Technology Assessment: Evaluation of 8 CGRP-Targeted Therapy Drugs for the Treatment of Migraine

Drug Design, Development and Therapy
Mengyi Li, Siyong Huang, Jiabao Li, Xiao Hu, Jisheng Chen Key Specialty of Clinical Pharmacy, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaCorrespondence: Jisheng Chen, Key Specialty of ...
Li M, Huang S, Li J, Hu X, Chen J
doaj  

The Calcitonin/Calcitonin Gene-Related Peptide Family in Invertebrate Deuterostomes

Frontiers in Endocrinology, 2018
Calcitonin (CT)/CT gene-related peptide (CGRP) family peptides (CT/CGRP family peptides) including CT, CGRP, adrenomedullin, amylin, and CT receptor-stimulating peptide have been identified from various vertebrates and perform a variety of important ...
Toshio Sekiguchi
doaj   +1 more source

Lacosamide in Migraine: Mechanistic Insights and Emerging Clinical Evidence

Neuropharmacology and Therapy
Migraine is a common and disabling neurological disorder that is often difficult to manage, despite treatments such as triptans, non-steroidal anti-inflammatory drugs (NSAIDs), and calcitonin gene-related peptide (CGRP)-targeted therapies. Lacosamide, an
Mehroz Mustafa
doaj   +1 more source

Efficacy and Safety of Rimegepant 75 Mg Oral Tablet, a CGRP Receptor Antagonist, for the Acute Treatment of Migraine: A Randomized, Double-Blind, Placebo-Controlled Trial [Corrigendum]

Journal of Pain Research
Lipton RB, Thiry A, Morris BA, Croop R. J Pain Res. 2024 Jul 22:17:2431–2441. The authors have advised that Figure 2 on page 2437 is incorrect. The text “150/241 (27.7%)” in the Placebo n/N (Risk) column for the row Freedom from MBS ...
Lipton RB, Thiry A, Morris BA, Croop R
doaj  

Efficacy and Safety of Rimegepant 75 mg Oral Tablet, a CGRP Receptor Antagonist, for the Acute Treatment of Migraine: A Randomized, Double-Blind, Placebo-Controlled Trial

Journal of Pain Research
Richard B Lipton,1 Alexandra Thiry,2 Beth A Morris,3 Robert Croop3 1Department of Neurology and the Montefiore Headache Center, Albert Einstein College of Medicine, Bronx, NY, USA; 2Biostatistics, Pfizer, Inc., New York, NY, USA; 3Clinical Operations (BM)
Lipton RB, Thiry A, Morris BA, Croop R
doaj  

A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure

Frontiers in Pharmacology
BackgroundAlpha-calcitonin gene-related peptide (α-CGRP) is a cardioprotective neuropeptide. However, due to low bioavailability, its use as a therapeutic agent is limited.
Ambrish Kumar, Sarah Deloach, Lernix Williams, Donald J. DiPette, Jay D. Potts   +4 more
doaj   +1 more source

The Arrival of Anti-CGRP Monoclonal Antibodies in Migraine

Neurotherapeutics, 2022
Fred Cohen, Hsiangkuo Yuan, E. M. G. DePoy, S. Silberstein   +3 more
semanticscholar   +1 more source