Results 21 to 30 of about 33,931 (282)

Calcitonin gene-related peptide is a stimulator of renin secretion [PDF]

, 1988
Calcitonin gene-related peptide (CGRP) was found to stimulate renin secretion in vivo in normal human volunteers. Moreover, CGRP stimulated the release of renin in vitro from isolated rat renal juxtaglomerular cells (half-maximal effective concentration [
Fischer, J. A., R Muff, Gnädinger, M. P., Uehlinger, D. E., Weidmann, P., A Kurtz, M P Gnädinger, W Born, Muff, R., J M Lundberg, T Hökfelt, P Weidmann, Kurtz, Armin, Lundberg, J. M., D E Uehlinger, Born, W., Millberg, B. I., Hökfelt, T., J A Fischer, B I Millberg   +19 more
core   +1 more source

DataSheet1_Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo.docx

, 2022
Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as anti ...
Sung Hyun Yang (2156953), Chia-Lin Chuang (12204833), Rebekah L. Bower (5674772), Elyse T. Williams (12204836), Debbie L. Hay (2323294), Andrew Siow (4768143), Paul W. R. Harris (8097566), Margaret A. Brimble (574926), Shanan Chand (12204842), Christopher S. Walker (4369444), Jakeb S. S. M. Petersen (12204839), Aqfan Jamaluddin (12204830), Kerry M. Loomes (2819842)   +12 more
core   +1 more source

Role of Calcitonin Gene-Related Peptide in Nociceptive Modulationin Anterior Cingulate Cortex of Naïve Rats and Rats With Inflammatory Pain

Frontiers in Pharmacology, 2020
It is known that calcitonin gene-related peptide (CGRP) plays a key role in pain modulation in the brain. There are high expressions of CGRP and CGRP receptor in anterior cingulate cortex (ACC), an important brain structure in pain modulation.
Ke-Sai Hou, Lin-Lin Wang, Hong-Bo Wang, Feng-Hua Fu, Long-Chuan Yu, Long-Chuan Yu   +5 more
doaj   +1 more source

Six-month therapy of CGRP monoclonal antibodies in real-world clinical practice: an interim analysis of efficacy and safety data

Медицинский совет, 2022
Introduction. Migraine is one of the most common disabling neurological disorders. Recently developed monoclonal antibodies to calcitonin gene-related peptide (CGRP) or its receptor are the first targeted medication for preventive therapy of both ...
N. V. Vashchenko, A. M. Uzhakhov, M. V. Bogorodskaya, D. Z. Korobkova, Ju. E. Azimova, K. V. Skorobogatykh   +5 more
doaj   +1 more source

Intranasal calcitonin gene-related peptide administration impairs fear memory retention in mice through the PKD/p-HDAC5/Npas4 pathway

Scientific Reports, 2022
The calcitonin gene-related peptide (CGRP) suppresses fear memory retention in mice. Although intracerebroventricular administration of CGRP alters the fear memory processes, making it a promising therapeutic strategy for post-traumatic stress disorder ...
Narumi Hashikawa-Hobara, Yoshikazu Yoneyama, Kyoushiro Fujiwara, Naoya Hashikawa   +3 more
doaj   +1 more source

CGRP-MoAbs – «game changer» in der Migräneprophylaxe? [PDF]

, 2019
Die Prophylaxe der Migräne ist kein einfaches Unterfangen. Aus der Vielzahl der verwendeten Substanzklassen lässt sich schliessen, dass keine einzige einen hinreichenden Nutzen für schwer Betroffene bringt.
Sandor, Peter S., Pohl, Heiko, Sandor, Peter S, Fischer, Urs, Gantenbein, Andreas R., Gantenbein, Andreas R   +5 more
core   +2 more sources

Serotonin and CGRP in Migraine [PDF]

Annals of Neurosciences, 2012
Migraine is defined as recurrent attack of headache that are commonly unilateral and accompanied by gastrointestinal and visual disorders. Migraine is more prevalent in females than males with a ratio of 3:1. It is primarily a complex neurovascular disorder involving local vasodilation of intracranial, extracerebral blood vessels and simultaneous ...
Aggarwal, Milan, Puri, Veena, Puri, Sanjeev   +2 more
openaire   +2 more sources

Amylin/CGRP [PDF]

, 2013
This chapter focuses on the anorectic action of the pancreatic hormone amylin and the structurally related peptide calcitonin-gene related peptide (CGRP).
Lutz, T A, Thomas A. Lutz
core   +1 more source

Treatment Patterns for Calcitonin Gene-Related Peptide Monoclonal Antibodies Including Galcanezumab versus Conventional Preventive Treatments for Migraine: A Retrospective US Claims Study

Patient Preference and Adherence, 2022
Oralee J Varnado,1 Janna Manjelievskaia,2 Wenyu Ye,1 Allison Perry,2 Kory Schuh,1 Richard Wenzel1 1Value, Evidence, and Outcomes, Eli Lilly and Company, Indianapolis, IN, USA; 2Watson Health Life Sciences, Research & Analytics, IBM Watson Health ...
Varnado OJ, Manjelievskaia J, Ye W, Perry A, Schuh K, Wenzel R   +5 more
doaj  

CGRP outflow into jugular blood and cerebrospinal fluid and permeance for CGRP of rat dura mater [PDF]

, 2021
Background Calcitonin gene-related peptide (CGRP) is released from activated meningeal afferent fibres in the cranial dura mater, which likely accompanies severe headache attacks.
Birgit Vogler, Risch, Miriam, Messlinger, Karl, Karl Messlinger, Vogler, Birgit, Mária Dux, Miriam Risch, Dux, Mária   +7 more
core   +1 more source