Lipidated calcitonin gene-related peptide (CGRP) peptide antagonists retain CGRP receptor activity and attenuate CGRP action in vivo [PDF]
, 2022 Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as anti ...
Harris, Paul W. R. +12 more
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Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]
, 2011 Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Beat Müller +21 more
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The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]
, 2013 The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Poyner, David +18 more
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CGRP-induced headache and hemodynamic response for prediction of therapy based on CGRP antagonism [PDF]
, 2023 Migraine is increasingly recognized as a disorder of the calcitonin gene-related peptide (CGRP) pathway. However, other factors are involved in migraine pathophysiology such as vasoactive intestinal peptide (VIP) and PACAP-38.
Zaletel, Marjan
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Recent advances in targeting calcitonin gene-related peptide for the treatment of menstrual migraine
Medicine, 2022 . Menstrual migraine (MM) has a longer duration and higher drug resistance than non-perimenstrual migraine. Calcitonin gene-related peptide (CGRP) and CGRP receptors are expressed in the peripheral and central nervous systems throughout the ...
Yan Jiang, MMed, Zhen-Lun Huang, BMed
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Renal mesangium is a target for calcitonin gene-related peptide [PDF]
, 1989 Rat calcitonin gene-related peptide (CGRP alpha; EC50, 1 nM) was shown to stimulate cAMP formation in cultured rat renal mesangial cells. CGRP concentration dependently (EC50, 1 nM) also inhibited contraction of mesangial cells by angiotensin II (10 nM).
Schurek, H. J. +15 more
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Calcitonin gene products and the kidney [PDF]
, 1989 Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation.
Fischer, J. A., Kurtz, Armin, Muff, R.
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Calcitonin gene-related peptide is a potential autoantigen for CD4 T cells in type 1 diabetes
Frontiers in Immunology, 2022 The calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide with critical roles in the development of peripheral sensitization and pain. One of the CGRP family peptides, islet amyloid polypeptide (IAPP), is an important autoantigen in type
Wei Li +9 more
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CGRP-, SP- and NF200-positive fibers.
, 2020 a: The length of dermal CGRP-positive nerve fibers did not differ between FMS patients and controls. b: The length of dermal SP-positive nerve fibers did not differ between FMS patients and controls.
Dimitar Evdokimov (8292651) +4 more
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The Journal of Headache and Pain, 2022 Background The clinical use of calcitonin gene-related peptide receptor (CGRP-R) antagonists and monoclonal antibodies against CGRP and CGRP-R has offered new treatment possibilities for migraine patients.
Sanne Hage La Cour +6 more
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