Results 11 to 20 of about 35,141 (247)

CGRP: from history to clinical application - A review [PDF]

Headache Medicine, 2020
The role of calcitonin gene-related peptide (CGRP) and its receptor have played an important role in migraine for the last decades due to development of therapies that target their receptors at the trigeminal pain system, aiming at prevention or relief ...
Afonso Henrique Aragao, Joel Sanabria Duarte, Daniel Benzecry Almeida, Ricardo Ramina   +3 more
doaj   +2 more sources

Mechanical Distraction Engages a Neuro-Immune Program to Drive Regenerative Soft-Tissue Healing in Ilizarov Bone Transport. [PDF]

Adv Sci (Weinh)
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Zhu Y, Chen J, Wen X, Tang K, Gao L, Wang C, Feng Y, Qin SH, Chen T, Yu X.   +9 more
europepmc   +2 more sources

Preliminary evidence of long-term safety and effectiveness of anti-CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52-week follow-up retrospective study. [PDF]

Epilepsia Open
Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort of adults with comorbid migraine and epilepsy treated with anti‐CGRP ...
Romozzi M, Burgalassi A, Ceriello F, Martino P, Sette G, Pistoia F, Placidi F, Centonze D, Pani L, Canonichesi J, Vollono C, Calabresi P, Albanese M, Iannone LF.   +13 more
europepmc   +2 more sources

CGRP-induced headache and hemodynamic response for prediction of therapy based on CGRP antagonism [PDF]

, 2023
Migraine is increasingly recognized as a disorder of the calcitonin gene-related peptide (CGRP) pathway. However, other factors are involved in migraine pathophysiology such as vasoactive intestinal peptide (VIP) and PACAP-38.
Zaletel, Marjan
core   +1 more source

The Anti-CGRP Antibody Fremanezumab Lowers CGRP Release from Rat Dura Mater and Meningeal Blood Flow [PDF]

, 2022
Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide (CGRP) belong to a new generation of therapeutics that are effective in the prevention of migraine.
Messlinger, Karl, Dux, Mária, Birgit Vogler, Kuhn, Annette, Annette Kuhn, Vogler, Birgit, Mackenzie, Kimberly D., Karl Messlinger, Mária Dux, Kimberly D. Mackenzie, Stratton, Jennifer, Jennifer Stratton   +11 more
core   +1 more source

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]

, 2011
Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Beat Müller, Tanja Radimerski, Ralph Peterli, Ulrich Keller, Christ-Crain, Mirjam, Daniel M. Frey, Timper, Katharina, Frey, Daniel M., Mirjam Christ-Crain, Jean Grisouard, Häring, Andreas, Zulewski, Henryk, Keller, Ulrich, Grisouard, Jean, Katharina Timper, Henryk Zulewski, Radimerski, Tanja, Müller, Beat, Kaethi Dembinski, Dembinski, Kaethi, Andreas Häring, Peterli, Ralph, Christ-Crain M, Peterli R, Häring A, Frey DM, Müller B, Grisouard J, Keller U, Radimerski T, Zulewski H, Dembinski K, Timper K   +32 more
core   +1 more source

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]

, 2013
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Karakullukcu, Z. Gamze, Woolley, Michael J, Barwell, James, Karakullukcu, Z Gamze, Poyner, David R., Smith, Kevin J., Taddese, Bruck, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Watkins, Harriet A., Watkins, Harriet A, Conner, Alex C, Smith, Kevin J, Woolley, Michael J.   +18 more
core   +1 more source

Renal mesangium is a target for calcitonin gene-related peptide [PDF]

, 1989
Rat calcitonin gene-related peptide (CGRP alpha; EC50, 1 nM) was shown to stimulate cAMP formation in cultured rat renal mesangial cells. CGRP concentration dependently (EC50, 1 nM) also inhibited contraction of mesangial cells by angiotensin II (10 nM).
Schurek, H. J., Heckmann, U., Scholz, Holger, Fischer, J. A., Bauer, Christian, Jelkmann, W., Muff, R., Kurtz, Armin, Lipp, H. P., Eckardt, Kai-Uwe, Roman Muff, Schurek HJ, Kai-Uwe Eckardt, Eckardt KU, Fischer JA, Bauer C, Armin Kurtz, Holger Scholz, Lipp HP, Heckmann U, Jan A. Fischer, Kurtz A, Jelkmann W, Christian Bauer, Hans-Joachim Schurek, Hans-Peter Lipp, Wolfgang Jelkmann, Uwe Heckmann, Scholz H, Muff R   +29 more
core   +1 more source

Calcitonin gene products and the kidney [PDF]

, 1989
Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation.
Fischer, J. A., Kurtz, Armin, Muff, R., Fischer JA, Kurtz A, Muff R   +5 more
core   +1 more source

CGRP-, SP- and NF200-positive fibers.

, 2020
a: The length of dermal CGRP-positive nerve fibers did not differ between FMS patients and controls. b: The length of dermal SP-positive nerve fibers did not differ between FMS patients and controls.
Dimitar Evdokimov (8292651), Johanna Frank (8292657), Nurcan Üçeyler (226246), Philine Dinkel (8292654), Claudia Sommer (230646)   +4 more
core   +1 more source