Results 11 to 20 of about 43,027 (269)
Cell, 2022 Summary Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which sensory neurons communicate with epithelial cells to mediate gut barrier protection at homeostasis and during inflammation are not well understood.
Amanda Jacobson +2 more
exaly +2 more sources
Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting
Expert Opinion on Therapeutic Targets, 2020 Introduction: The neuropeptide calcitonin gene-related peptide (CGRP) is recognized as a critical player in migraine pathophysiology. Excitement has grown regarding CGRP because of the development and clinical testing of drugs targeting CGRP or its ...
Anne-Sophie Wattiez +2 more
exaly +2 more sources
Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation
Immunity, 2019 Summary Innate lymphocytes maintain tissue homeostasis at mucosal barriers, with group 2 innate lymphoid cells (ILC2s) producing type 2 cytokines and controlling helminth infection.
Tanel Mahlakõiv +2 more
exaly +2 more sources
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
Nature, 2018 Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the calcitonin receptor-like receptor (CLR) class B G-protein-coupled receptor and a type ...
Yi-Lynn Liang +2 more
exaly +2 more sources
Frontiers in Physiology, 2018 Calcitonin gene-related peptide (CGRP) is a highly potent vasoactive peptide released from sensory nerves, which is now proposed to have protective effects in several cardiovascular diseases.
Zizheng Kee +2 more
exaly +2 more sources
The Journal of Headache and Pain, 2019 BackgroundMonoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brain barrier the trigeminal system has
Jacob C. A. Edvinsson +6 more
semanticscholar +3 more sources
Prevention of migraine with monoclonal antibodies against CGRP or the CGRP receptor
Neurological Research and Practice, 2020 Abstract Monoclonal antibodies against the calcitonin gene-related peptide (CGRP) receptor (Erenumab) or against CGRP (Eptinezumab, Fremanezumab, Galcanezumab) are new substances for the preventive treatment of migraine. They represent an extension of the therapeutic options, which already exist in migraine prevention. In randomized, placebo-controlled
Hans-Christoph Diener +13 more
openaire +3 more sources
CGRP physiology, pharmacology, and therapeutic targets: Migraine and beyond.
Physiological Reviews, 2022 Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory neurons, as well as in other cell types, such as motor neurons and ...
A. Russo, D. Hay
semanticscholar +1 more source
Mode and site of action of therapies targeting CGRP signaling
The Journal of Headache and Pain, 2023 Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system.
Alejandro Labastida-Ramírez +12 more
semanticscholar +1 more source
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
The Journal of Headache and Pain, 2023 The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis.
Adisa Kuburas, A. Russo
semanticscholar +1 more source