Calcitonin gene-related peptide is a potential autoantigen for CD4 T cells in type 1 diabetes
Frontiers in Immunology, 2022 The calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide with critical roles in the development of peripheral sensitization and pain. One of the CGRP family peptides, islet amyloid polypeptide (IAPP), is an important autoantigen in type
Wei Li +9 more
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Acute treatment of migraine: quo vadis? [PDF]
, 2017 Migraine represents the third cause of disability in the worldwide population aged under 50 years. Facing this enormous social impact, only onabotulinumtoxinA has been evaluated, on serendipity basis, as effective chronic migraine preventative ...
Martelletti, Paolo
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Identification of a rhythmic firing pattern in the enteric nervous system that generates rhythmic electrical activity in smooth muscle [PDF]
, 2018 The enteric nervous system (ENS) contains millions of neurons essential for organization of motor behavior of the intestine. It is well established that the large intestine requires ENS activity to drive propulsive motor behaviors.
Brookes, Simon J +10 more
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On Tribo-Test Machine Integrating Pin-on-Disc and Block-on-Ring
Tribology Online, 2007 A concept of integrating more than one tribo-technique, Pin-on-Disc (POD) and Block-on-Ring (BOR), working simultaneously under same test conditions against same counterface is introduced in a new multi-tribo-test-machine. In this machine, different wear
Belal F. Yousif, Nabil. S. M. El-Tayeb
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N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. [PDF]
, 2017 N-Arachidonoyl dopamine (NADA) is an endogenous lipid that potently activates the transient receptor potential vanilloid 1 (TRPV1), which mediates pain and thermosensation. NADA is also an agonist of cannabinoid receptors 1 and 2.
Hellman, Judith +7 more
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Journal of Integrative NeuroscienceBackground: Bone cancer pain (BCP) is a common primary or metastatic bone cancer complication. Netrin-1 plays an essential role in neurite elongation and pain sensitization.
Zhihao Gong +6 more
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The therapeutic armamentarium in migraine is quite elderly. [PDF]
, 2014 Global Burden of Disease 2010 study considers migraine as one of the most important noncommunicable diseases in the world, classifying it third in terms of global prevalence (14.70%): it sums up the 54.19% of all the years of life lived with disabilities
Martelletti, Paolo
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11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches : Rome, Italy. 01-03 December 2017 [PDF]
, 2017 . Aims of the study were explore the relationship between peripheral chromatic and central visual dysfunction evaluating also the presence of functional receptor impairment in patients with migraine, with and without aura examined ...
Brighina, F +5 more
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The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source
The impact of limbic sensitization on the efficacy of fremanezumab therapy in migraine patients
Клинический разбор в общей медицинеBackground. Migraine is a common disease that affects about 1 billion people worldwide. Factors affecting the limbic system play a major role in the migraine chronification. Dysfunction of the limbic system underlies many non-painful symptoms of migraine.
Anna Yu. Timokhovich +4 more
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