Results 41 to 50 of about 45,236 (268)

Intranasal calcitonin gene-related peptide administration impairs fear memory retention in mice through the PKD/p-HDAC5/Npas4 pathway

Scientific Reports, 2022
The calcitonin gene-related peptide (CGRP) suppresses fear memory retention in mice. Although intracerebroventricular administration of CGRP alters the fear memory processes, making it a promising therapeutic strategy for post-traumatic stress disorder ...
Narumi Hashikawa-Hobara, Yoshikazu Yoneyama, Kyoushiro Fujiwara, Naoya Hashikawa   +3 more
doaj   +1 more source

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]

, 2011
Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Christ-Crain, Mirjam, Dembinski, Kaethi, Frey, Daniel M., Grisouard, Jean, Häring, Andreas, Keller, Ulrich, Müller, Beat, Peterli, Ralph, Radimerski, Tanja, Timper, Katharina, Zulewski, Henryk   +10 more
core   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Comparison of Early-onset Efficacy of Anti-calcitonin Gene-related Peptide Monoclonal Antibodies for Patients with Migraine in Real-world Clinical Practice: Study Protocol for an Exploratory Clinical Trial

Neurologia Medico-Chirurgica
Three anti-calcitonin gene-related peptide monoclonal antibodies (CGRP-mAbs) are available in Japan: galcanezumab, fremanezumab, and erenumab. Early-onset efficacy has been demonstrated for each CGRP-mAb in comparison with placebo, but differences among ...
Takafumi TANEI, Satoshi MAESAWA, Yusuke NISHIMURA, Tomotaka ISHIZAKI, Yoshitaka NAGASHIMA, Miki HASHIDA, Shun YAMAMOTO, Masahiko ANDO, Yachiyo KUWATSUKA, Atsushi HASHIZUME, Toshihiko WAKABAYASHI, Ryuta SAITO   +11 more
doaj   +1 more source

Dietary capsaicin normalizes CGRP peptidergic DRG neurons in experimental diabetic peripheral neuropathy

Scientific Reports, 2021
Diabetic sensory neuropathy leads to impairment of peripheral sensory nerves and downregulation of calcitonin gene-related peptide (CGRP) in a functionally specific subset of peripheral sensory neurons mediating pain. Whether CGRP plays a neuroprotective
Xiao-Yi Zhang, Zheng Guo, Tu-Ping Li, Tao Sun   +3 more
doaj   +1 more source

TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione [PDF]

, 2016
Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of ...
Benemei, Silvia, Coppi, Elisabetta, De Logu, Francesco, Di Tommaso, Mariarosaria, Fusi, Camilla, Geppetti, Pierangelo, Li Puma, Simone, Marone, Ilaria M., Materazzi, Serena, Moneti, Gloriano, Morice, Alyn H., Nassini, Romina, Sadofsky, Laura R., Susini, Tommaso, Terreni, Alessandro, Tonello, Raquel   +15 more
core   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Role of calcitonin gene-related peptide in bone repair after cyclic fatigue loading. [PDF]

PLoS ONE, 2011
Calcitonin gene related peptide (CGRP) is a neuropeptide that is abundant in the sensory neurons which innervate bone. The effects of CGRP on isolated bone cells have been widely studied, and CGRP is currently considered to be an osteoanabolic peptide ...
Susannah J Sample, Zhengling Hao, Aliya P Wilson, Peter Muir   +3 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease [PDF]

, 2008
Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammatory mediators, we hypothesized that transfected CGRP gene
Hongsui Wu, Huanxin Yang, Jian Su, Jian Zhuang, Jianguang Chen, Shiliang Chen, Xiaoning Zhang, Yuhui Zheng, Zhihong Chen   +8 more
core   +1 more source