Results 11 to 20 of about 34,747 (233)

Calcitonin gene-related peptide is a stimulator of renin secretion

, 1988
Calcitonin gene-related peptide (CGRP) was found to stimulate renin secretion in vivo in normal human volunteers. Moreover, CGRP stimulated the release of renin in vitro from isolated rat renal juxtaglomerular cells (half-maximal effective concentration [
Fischer, J. A., R Muff, Gnädinger, M. P., Uehlinger, D. E., Weidmann, P., A Kurtz, M P Gnädinger, W Born, Muff, R., J M Lundberg, T Hökfelt, P Weidmann, Kurtz, Armin, Lundberg, J. M., D E Uehlinger, Born, W., Millberg, B. I., Hökfelt, T., J A Fischer, B I Millberg   +19 more
core   +1 more source

Calcitonin gene products and the kidney

, 1989
Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation.
Fischer, J. A., Kurtz, Armin, Muff, R.
core   +1 more source

Calcitonin-gene related peptide and disease activity in cluster headache [PDF]

, 2019
Objective: To investigate the role of calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide in cluster headache, we measured these vasoactive peptides interictally and ...
Jensen, Rigmor H., Jørgensen, Niklas Rye, Vollesen, Anne Luise H, Beske, Rasmus P., Snoer, Agneta, Vollesen, Anne Luise H., Beske, Rasmus P, Martinussen, Torben, Hoffmann, Jan; id_orcid, Jensen, Rigmor H, Ashina, Messoud, Fahrenkrug, Jan, Guo, Song, Hoffmann, Jan   +13 more
core   +1 more source

Renal mesangium is a target for calcitonin gene-related peptide

, 1989
Rat calcitonin gene-related peptide (CGRP alpha; EC50, 1 nM) was shown to stimulate cAMP formation in cultured rat renal mesangial cells. CGRP concentration dependently (EC50, 1 nM) also inhibited contraction of mesangial cells by angiotensin II (10 nM).
Schurek, H. J., Heckmann, U., Scholz, Holger, Fischer, Jan A., Fischer, J. A., Bauer, Christian, Lipp, Hans-Peter, Jelkmann, W., Muff, R., Heckmann, Uwe, Kurtz, Armin, Lipp, H. P., Schurek, Hans-Joachim, Jelkmann, Wolfgang, Muff, Roman, Eckardt, Kai-Uwe   +15 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Safety and Efficacy of 10 kHz Spinal Cord Stimulation for the Treatment of Refractory Chronic Migraine: A Prospective Long‐Term Open‐Label Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Background Refractory chronic migraine (rCM) is a highly disabling condition for which novel safe and effective treatments are needed. Safety and long‐term efficacy of paresthesia‐free high cervical 10 kHz spinal cord stimulation (SCS) were here prospectively evaluated for the treatment of rCM.
Adnan Al‐Kaisy, Stefano Palmisani, Roy Carganillo, Samuel Wesley, David Pang, Anand Rotte, Angela Santos, Giorgio Lambru   +7 more
wiley   +1 more source

Role of Calcitonin Gene-Related Peptide in Inhibitory Neurotransmission to the Pig Bladder Neck

, 2011
Purpose: We studied the role of calcitonin gene-related peptide in nonadrenergic, noncholinergic neurotransmission to the pig bladder neck. Materials and Methods: We used immunohistochemical techniques to determine the distribution of calcitonin gene ...
Joaquín Carballido, García-Sacristán, Albino, Hernández Rodríguez, Medardo Vicente, Medardo Hernández, Paz Recio, Ana Martínez-Sáenz, Orensanz, Luis M., Carballido, Joaquín, María Pilar Martínez, Bustamante, Salvador, Luis M. Orensanz, Martínez Sainz, María Del Pilar, Vítor S. Fernandes, Salvador Bustamante, Dolores Prieto, Leite Fernandes, Vitor Samuel, Albino García-Sacristán, Martínez-Sáenz, Ana, Recio Visedo, María Paz, Prieto Ocejo, Dolores   +19 more
core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source