Results 31 to 40 of about 56,119 (256)

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B [PDF]

, 2015
Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
A Adebiyi, A Cheong, A Cogolludo, A Moreno-Dominguez, AJ Wilson, AM Brainard, B Kyle, B Razani, B Razani, C Dart, C Dart, Carl P. Nelson, CL Moore, CP Nelson, CP Nelson, DP McEwen, DW Carr, EA Aiello, EA Aiello, EA Ko, EA Ko, F Plane, GC Wellman, GI Purves, H Li, H Miyoshi, HS Mason, IA Greenwood, J Couet, J Moral-Sanz, JB Stott, JD Scott, JD Turner, Jennifer L. Brignell, JM Quayle, Jonathon M. Willets, JR Martens, KD Luykenaar, KS Park, LF Santana, LJ Sampson, LM Davies, M Colledge, Mark S. Shapiro, Matthew D. Perry, MF Navedo, MG Gold, MT Nelson, NM Alto, NN Orie, Noel W. Davies, O Clement-Chomienne, P Skroblin, R. A. John Challiss, RD Rainbow, RD Rainbow, RD Rainbow, RH Cox, RT Dobrowsky, SA Barman, VM Coghlan, Y Hayabuchi, Y Hayabuchi, Y Hayabuchi, Y Yang   +64 more
core   +5 more sources

N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. [PDF]

, 2017
N-Arachidonoyl dopamine (NADA) is an endogenous lipid that potently activates the transient receptor potential vanilloid 1 (TRPV1), which mediates pain and thermosensation. NADA is also an agonist of cannabinoid receptors 1 and 2.
Hellman, Judith, Lawton, Samira K, Prakash, Arun, Schumacher, Mark, Tran, Alphonso, Wilhelmsen, Kevin, Wong, Erika, Xu, Fengyun   +7 more
core   +2 more sources

Calcitonin Gene-Related Peptide (CGRP) and Cluster Headache

Brain Sciences, 2020
Cluster headache (CH) is a severe primary headache with a prevalence of 1/1000 individuals, and a predominance in men. Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ...
Andrea Carmine Belin, Caroline Ran, Lars Edvinsson   +2 more
doaj   +1 more source

Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells. [PDF]

, 2005
BackgroundDeregulation of the Wnt/ beta-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues. Mutations in components of this pathway result in beta-catenin stabilization and
Ashworth, Alan, Enver, Tariq, Kenny, Paraic A   +2 more
core   +3 more sources

Exercise alleviates hypoalgesia and increases the level of calcitonin gene-related peptide in the dorsal horn of the spinal cord of diabetic rats

Clinics, 2012
OBJECTIVE: The aim of this study was to evaluate the effects of treadmill training on nociceptive sensitivity and immunoreactivity to calcitonin gene-related peptide in the dorsal horn of the spinal cord of diabetic rats.
Patrícia Severo do Nascimento, Gisele Agustini Lovatel, Jocemar Ilha, Léder L. Xavier, Beatriz D'Agord Schaan, Matilde Achaval   +5 more
doaj   +1 more source

Magnesium-based implants: Beyond fixators

Journal of Orthopaedic Translation, 2017
The mystery behind magnesium-induced bone formation is revealed by linking the neuropeptide(s) from sensory nerves with the osteogenic differentiation of stem cells in the periosteum.
Xiaodan Chen
doaj   +1 more source

New players in the preventive treatment of migraine. [PDF]

, 2015
Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed ...
Mitsikostas, Dimos D, Rapoport, Alan M
core   +3 more sources

How to integrate monoclonal antibodies targeting the calcitonin gene-related peptide or its receptor in daily clinical practice

The Journal of Headache and Pain, 2019
Background Migraine is a major public health issue associated with significant morbidity, considerable negative impact on quality of life, and significant socioeconomic burden.
Cindy Tiseo, Raffaele Ornello, Francesca Pistoia, Simona Sacco   +3 more
doaj   +1 more source

The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratus [PDF]

, 2012
The work reported here was supported by a grant from the University of London Central Research ...
Elphick, MR, Rowe, ML
core   +1 more source

Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin [PDF]

Biochemical Journal, 1991
Near-u.v. and far-u.v. c.d. spectra of human alpha-calcitonin-gene-related peptide (h alpha CGRP), analogues and fragments of CGRP and amylin were recorded in aqueous solution and in trifluoroethanol (TFE)/water mixtures. All peptides contained significant amounts of alpha-helix in aqueous solution, and this amount increased on adding TFE.
J A, Hubbard, S R, Martin, L C, Chaplin, C, Bose, S M, Kelly, N C, Price   +5 more
openaire   +2 more sources