Results 31 to 40 of about 36,287 (271)

Magnesium-based implants: Beyond fixators

Journal of Orthopaedic Translation, 2017
The mystery behind magnesium-induced bone formation is revealed by linking the neuropeptide(s) from sensory nerves with the osteogenic differentiation of stem cells in the periosteum.
Xiaodan Chen
doaj   +1 more source

How to integrate monoclonal antibodies targeting the calcitonin gene-related peptide or its receptor in daily clinical practice

The Journal of Headache and Pain, 2019
Background Migraine is a major public health issue associated with significant morbidity, considerable negative impact on quality of life, and significant socioeconomic burden.
Cindy Tiseo, Raffaele Ornello, Francesca Pistoia, Simona Sacco   +3 more
doaj   +1 more source

Hypersensitivity to calcitonin gene-related peptide in chronic migraine

, 2021
Objective: To investigate if calcitonin gene-related peptide infusion induces migraine-like attacks in chronic migraine patients. Methods: Fifty-eight patients with chronic migraine, either with or without headache on the experimental day, were assessed ...
Ashina, Håkan, Zhuang, Zixuan Alice, Lopez Lopez, Cristina, Snellman, Josefin, Ashina, Messoud, Iljazi, Afrim, Schytz, Henrik Winther   +6 more
core   +1 more source

Calcitonin gene-related peptide is potential therapeutic target of osteoporosis

Heliyon, 2022
Osteoporosis is a skeletal disorder characterised by the decrease of bone mineral density and is becoming prevalent with the entry of an ageing era.
Hua Wu, Xue-qin Lin, Yu Long, Jing Wang
doaj   +1 more source

Calcitonin gene-related peptide is a stimulator of renin secretion

, 1988
Calcitonin gene-related peptide (CGRP) was found to stimulate renin secretion in vivo in normal human volunteers. Moreover, CGRP stimulated the release of renin in vitro from isolated rat renal juxtaglomerular cells (half-maximal effective concentration [
Fischer, J. A., R Muff, Gnädinger, M. P., Uehlinger, D. E., Weidmann, P., A Kurtz, M P Gnädinger, W Born, Muff, R., J M Lundberg, T Hökfelt, P Weidmann, Kurtz, Armin, Lundberg, J. M., D E Uehlinger, Born, W., Millberg, B. I., Hökfelt, T., J A Fischer, B I Millberg   +19 more
core   +1 more source

Calcitonin gene products and the kidney

, 1989
Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation.
Fischer, J. A., Kurtz, Armin, Muff, R.
core   +1 more source

Calcitonin-gene related peptide and disease activity in cluster headache [PDF]

, 2019
Objective: To investigate the role of calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide in cluster headache, we measured these vasoactive peptides interictally and ...
Jensen, Rigmor H., Jørgensen, Niklas Rye, Vollesen, Anne Luise H, Beske, Rasmus P., Snoer, Agneta, Vollesen, Anne Luise H., Beske, Rasmus P, Martinussen, Torben, Hoffmann, Jan; id_orcid, Jensen, Rigmor H, Ashina, Messoud, Fahrenkrug, Jan, Guo, Song, Hoffmann, Jan   +13 more
core   +1 more source

Renal mesangium is a target for calcitonin gene-related peptide

, 1989
Rat calcitonin gene-related peptide (CGRP alpha; EC50, 1 nM) was shown to stimulate cAMP formation in cultured rat renal mesangial cells. CGRP concentration dependently (EC50, 1 nM) also inhibited contraction of mesangial cells by angiotensin II (10 nM).
Schurek, H. J., Heckmann, U., Scholz, Holger, Fischer, Jan A., Fischer, J. A., Bauer, Christian, Lipp, Hans-Peter, Jelkmann, W., Muff, R., Heckmann, Uwe, Kurtz, Armin, Lipp, H. P., Schurek, Hans-Joachim, Jelkmann, Wolfgang, Muff, Roman, Eckardt, Kai-Uwe   +15 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source