Results 101 to 110 of about 113,289 (321)

Astrocytic Hevin/SPARCL‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging

Aging Cell, EarlyView.
Hevin/Sparcl‐1 is a synaptogenic protein secreted by astrocytes. We used adeno‐associated virus (AAV) to increase its expression in hippocampal astrocytes of APP/PSEN1 mice, an animal model for Alzheimer's disease (AD). This procedure improved cognitive performance both in the AD model and in middle‐aged wild‐type animals.
Felipe Cabral‐Miranda, Ana Paula Bergamo Araujo, Danilo Bilches Medinas, Flávia Carvalho Alcantara Gomes   +3 more
wiley   +1 more source

American trypanosomiasis and Chagas disease: Sexual transmission

International Journal of Infectious Diseases, 2019
Objective: To contribute to the discussion on the research findings indicating the sexual transmission of American trypanosomiasis and Chagas disease in humans.
Clever Gomes, Adriana B. Almeida, Ana C. Rosa, Perla F. Araujo, Antonio R.L. Teixeira   +4 more
doaj  

Mortality Related to Chagas Disease and HIV/AIDS Coinfection in Brazil

Journal of Tropical Medicine, 2012
Chagas disease in patients with HIV infection represents a potentially serious event with high case fatality rates. This study describes epidemiological and clinical aspects of deaths related to Chagas disease and HIV/AIDS coinfection in Brazil, 1999 ...
Francisco Rogerlândio Martins-Melo, Alberto Novaes Ramos, Carlos Henrique Alencar, Jorg Heukelbach   +3 more
doaj   +1 more source

Risks of endemicity, morbidity and perspectives regarding the control of Chagas disease in the Amazon Region

Memorias do Instituto Oswaldo Cruz, 2012
Chagas disease, in the Amazon Region as elsewhere, can be considered an enzootic disease of wild animals or an anthropozoonosis, an accidental disease of humans that is acquired when humans penetrate a wild ecosystem or when wild triatomines invade human
José Rodrigues Coura, Angela CV Junqueira   +1 more
doaj   +1 more source

Genome and transcriptome studies of the protozoan parasites Trypanosoma cruzi and Giardia intestinalis [PDF]

arXiv, 2012
Trypanosoma cruzi and Giardia intestinalis are two human pathogens and protozoan parasites responsible for the diseases Chagas disease and giardiasis, respectively. Both diseases cause suffering and illness in several million individuals. The former disease occurs primarily in South America and Central America, and the latter disease occurs worldwide ...
arxiv  

Role of T. cruzi exposure in the pattern of T cell cytokines among chronically infected HIV and Chagas disease patients [PDF]

, 2017
OBJECTIVES: The impact of Chagas disease (CD) in HIV-infected patients is relevant throughout the world. In fact, the characterization of the adaptive immune response in the context of co-infection is important for predicting the need for interventions ...
Bezerra, Rita C., Freitas, Vera Lúcia Teixeira de, Ibrahim, Karim Yaqub, Sartori, Ana Marli Christovam, Shikanai-Yasuda, Maria Aparecida, Tozetto-Mendoza, Tania Regina, Vasconcelos, Dewton de Moraes   +6 more
core   +3 more sources

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Bosutinib mitigates inflammation in experimental sepsis

European Journal of Clinical Investigation, EarlyView.
Abstract Background Sepsis, a leading cause of death globally, lacks targeted and effective treatment. Its pathophysiology involves unbalanced inflammation, marked by a high release of inflammatory mediators, leukocyte recruitment, vascular changes and dysfunction of the nervous and respiratory systems. Src family tyrosine kinases (SFK) play a critical
C. M. C. Cunha, V. H. P. Abreu, V. Estato, G. M. V. Soares, B. P. T. Moraes, G. P. Oliveira, J. D. Silva, P. L. Silva, R. Immler, P. R. Rocco, M. Sperandio, A. R. Silva, P. T. Bozza, H. C. Castro‐Faria‐Neto, C. F. Gonçalves‐de‐Albuquerque   +14 more
wiley   +1 more source

Age-Standardized Mortality Rates Related to Cirrhosis in Brazil from 2000 to 2012: A Nationwide Analysis

Annals of Hepatology, 2017
Background Cirrhosis remains the most frequent liver-related cause of death worldwide and we aimed to evaluate its burden in Brazil from 2000 to 2012.Material and methods The Brazilian National Death Registry was analyzed from 2000 to 2012.
Hugo Perazzo, Antonio G. Pacheco, Raquel De Boni, Paula M. Luz, Juliana Fittipaldi, Sandra W. Cardoso, Beatriz Grinsztejn, Valdiléa G. Veloso   +7 more
doaj  

Spatio-temporal trends in mortality due to Chagas disease in the State of Bahia, Brazil, from 2008 to 2018 [PDF]

Revista da Sociedade Brasileira de Medicina Tropical
Background: Chagas disease is a silent illness with high mortality burden in many Latin American countries, such as Brazil. Bahia has the fourth highest mortality rate in Brazil.
Cristiane Medeiros Moraes de Carvalho, Gilmar Ribeiro-Jr, Rodrigo Gurgel-Gonçalves, Liane Santiago Andrade, Cicílio Alves Moraes, Maria Aparecida Araújo Figueiredo   +5 more
doaj   +1 more source