Results 11 to 20 of about 9,204,525 (344)

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

Nature Microbiology, 2022
Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized.
A. Padilla, Wei Wang, T. Akama, D. S. Carter, E. Easom, Y. Freund, J. Halladay, Yang Liu, S. Hamer, CL Hodo, Gregory K Wilkerson, D. Orr, B. White, Arlene J. George, Huifeng Shen, Yiru Jin, Michael Zhuo Wang, Susanna Tse, R. Jacobs, R. Tarleton   +19 more
semanticscholar   +1 more source

The translational challenge in Chagas disease drug development

Memórias do Instituto Oswaldo Cruz, 2022
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations.
J. Kratz, K. R. Gonçalves, Lavínia Md Romera, C. Moraes, P. Bittencourt-Cunha, S. Schenkman, E. Chatelain, S. Sosa-Estani   +7 more
semanticscholar   +1 more source

Overdiagnosis of vaccine allergy: Skin testing and challenge at a public specialized unit (CRIE) in Rio de Janeiro, Brazil

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Vaccination is an extremely safe public health intervention, but rare IgE-mediated adverse events must be identified to avoid the risk of anaphylaxis in the event of reexposure.
Luciana Gomes Pedro Brandão, PhD, MSc, MD, Mari Tuyama, PhD, MSc, MD, Flávio de Carvalho, MSc, RN, Ananza Taina da Silva Santos, MSc, RN, Alberto dos Santos de Lemos, MSc, MD, Marcellus Dias da Costa, MSc, MD, Emersom Cicilini Mesquita, PhD, MSc, MD, José Cerbino-Neto, PhD, MSc, MD, Margareth Catoia Varela, MSc, Pedro Emmanuel Alvarenga Americano do Brasil, PhD, MSc, MD, Angélica Varela Rondon, MSc, MD   +10 more
doaj   +1 more source

Chagas Disease [PDF]

Pediatrics In Review, 2016
Approximately 8 million people worldwide are infected by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. After a latent period that can last years or decades, 10% to 30% of infected people develop serious complications, such as cardiomyopathy or gastrointestinal dysfunction.
Tustin, Aaron W., Bowman, Natalie M.
openaire   +2 more sources

Benznidazole decreases the risk of chronic Chagas disease progression and cardiovascular events: A long-term follow up study

EClinicalMedicine, 2021
Background: Chagas disease (CD) remains an important endemic disease in Latin America. However, CD became globalized in recent decades. The majority of the chronically infected individuals did not receive etiologic treatment for several reasons, among ...
Alejandro M. Hasslocher-Moreno, Roberto M. Saraiva, Luiz H.C. Sangenis, Sergio S. Xavier, Andrea S. de Sousa, Andrea R. Costa, Marcelo T. de Holanda, Henrique H. Veloso, Fernanda S.N.S. Mendes, Filipe A.C. Costa, Marcio N. Boia, Pedro E.A.A. Brasil, Fernanda M. Carneiro, Gilberto M.Sperandio da Silva, Mauro F.F. Mediano   +14 more
doaj   +1 more source

Recommendations for Screening and Diagnosis of Chagas Disease in the United States

Journal of Infectious Diseases, 2021
Background Chagas disease affects an estimated 326 000–347 000 people in the United States and is severely underdiagnosed. Lack of awareness and clarity regarding screening and diagnosis is a key barrier.
Colin J. Forsyth, J. Manne‐Goehler, C. Bern, Jeffrey D. Whitman, N. Hochberg, M. Edwards, R. Marcus, Norman L. Beatty, Yagahira E Castro, C. Coyle, Paula Stigler-Granados, D. Hamer, J. Maguire, R. Gilman, S. Meymandi   +14 more
semanticscholar   +1 more source

Stroke in Chagas disease: from pathophysiology to clinical practice [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2022
Despite substantial progress toward its control, Chagas disease continues to be a major public health problem in Latin America and has become a global health concern.
Thaís Aparecida Reis Lage, Julia Teixeira Tupinambás, Lucas Bretas de Pádua, Matheus de Oliveira Ferreira, Amanda Cambraia Ferreira, Antonio Lucio Teixeira, Maria Carmo Pereira Nunes   +6 more
doaj   +1 more source

Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort

Tropical Medicine and Infectious Disease, 2020
Most patients with chronic Chagas disease (CD) present the indeterminate form and are at risk to develop the cardiac form. However, the actual rate of progression to the cardiac form is still unknown.
Alejandro Marcel Hasslocher-Moreno, Sergio Salles Xavier, Roberto Magalhães Saraiva, Luiz Henrique Conde Sangenis, Marcelo Teixeira de Holanda, Henrique Horta Veloso, Andrea Rodrigues da Costa, Fernanda de Souza Nogueira Sardinha Mendes, Pedro Emmanuel Alvarenga Americano do Brasil, Gilberto Marcelo Sperandio da Silva, Mauro Felippe Felix Mediano, Andrea Silvestre de Sousa   +11 more
doaj   +1 more source

Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV

Medical Mycology Case Reports, 2022
We present a rare condition of mixed C. neoformans and C. gattii infection in a person living with HIV with false-negative CrAg LFA in the CSF and co-infection with paracoccidioidomycosis.
Marcela de Faria Ferreira, Fabio Brito-Santos, Pedro Henrique Nascimento Theodoro, Marcos de Abreu Almeida, Marcia dos Santos Lazera, Luciana Trilles   +5 more
doaj   +1 more source

The Case for the Development of a Chagas Disease Vaccine: Why? How? When?

Tropical Medicine and Infectious Disease, 2021
Chagas disease is a major neglected tropical disease, transmitted predominantly by triatomine insect vectors, but also through congenital and oral routes. While endemic in the Americas, it has turned into a global disease.
Eric Dumonteil, Claudia P Herrera
semanticscholar   +1 more source