Results 71 to 80 of about 9,204,525 (344)

Antinociceptive and Anti‐inflammatory Effect of Nicandrin B Isolated From Datura ferox in Zebrafish

Chemistry &Biodiversity, EarlyView.
ABSTRACT Nicandrin B (Nic B), a withanolide isolated from Datura ferox leaves, was investigated for its antinociceptive and anti‐inflammatory effects in adult zebrafish (Danio rerio). Animals treated with Nic B (4, 20, and 40 mg/kg) showed no toxicity and maintained normal locomotor activity.
Jéssica Bezerra Maciel, Hortência Ribeiro Liberato, Antônio Wlisses da Silva, Maria Auxiliadora Solange Silva Gondim Pereira, Emanuela de Lima Rebouças, Francisco das Chagas L. Pinto, Matheus Nunes da Rocha, Maria Kueirislene Amâncio Ferreira, Janaina Serra Azul Monteiro Evangelista, Izabel Florindo Guedes, Marcia Machado Marinho, Emmanuel Silva Marinho, Andreia Ferreira de Castro Gomes, Otília Loiola Pessoa, Jane Eire Silva Alencar de Menezes, Hélcio Silva dos Santos   +15 more
wiley   +1 more source

CrAg screening strategy reduces definitive sequelae in people living with HIV

Discover Viruses
Background Screenning cryptococcal antigen (CrAg) of people living with HIV (PLHIV) reduces the morbidity and development of cryptococcal meningitis, but recent publications shows that it does not reduce mortality when comparable with a negative CrAg ...
Marcela de Faria Ferreira, Fabio Brito-Santos, Marcos de Abreu Almeida, Luciana Trilles, Marcia dos Santos Lazera   +4 more
doaj   +1 more source

Impact of migration on the occurrence of new cases of Chagas disease in Buenos Aires city, Argentina [PDF]

, 2013
Chagas disease, also known as American Trypanosomiasis, is endemic in the Americas, especially Central and South America. Chagas disease is a zoonotic disease caused by the parasite Trypanosoma cruzi.
Altcheh, Jaime Marcelo, Ballering, Griselda, Berenstein, Ada, Biancardi, Miguel Angel, Espejo Cozzi, Andres, Freillij, Hector, Garcia Bournissen, Facundo, Hernandez, Susana, Moroni, Samanta, Moscatelli, Guillermo, Schwarcz, Marta, Siniawski, Susana, Tarlovsky, Ana   +12 more
core   +2 more sources

Antimicrobial Activity and Chemical Constituents of Siparuna guianensis (Siparunaceae)

Chemistry &Biodiversity, EarlyView.
ABSTRACT Siparuna guianensis (Siparunaceae) is an Amazonian plant known by the popular name of Negramina. There are several reports of the use of this plant in folk medicine. In the present work, we decided to study its extracts, aiming at the isolation of compounds and verifying their antimicrobial activities.
Olência Mento Manuensa Vilanculo, Mayra Suelen da Silva Pinheiro, Luana Cardoso de Oliveira, Dayenne Alexa Araújo de Souza, Sandra Valeria Dias Cardoso, Sebastião da Cruz Silva, Patrícia Santana Barbosa Marinho, Andrey Moacir do Rosario Marinho   +7 more
wiley   +1 more source

Physical activity levels during COVID-19 pandemic and its associated factors in patients with Chagas disease

Frontiers in Medicine
BackgroundA better understanding of the consequences of the Coronavirus Disease 2019 (COVID-19) pandemic on lifestyle of patients with Chagas disease (ChD) is of paramount importance to facilitate the implementation of intervention strategies tailored to
Isis Gabrielli Gomes Xavier, Patrícia Mello Andrade, Rodrigo de Lima Vitor, Tayná Cruz Barros, Luciana Fernandes Portela, Marcelo Teixeira de Holanda, Luiz Henrique Conde Sangenis, Gilberto Marcelo Sperandio da Silva, Flavia Mazzoli-Rocha, Fernanda de Souza Nogueira Sardinha Mendes, Andréa Rodrigues da Costa, Marcel de Souza Borges Quintana, Alejandro Marcel Hasslocher-Moreno, Itauá Leston Araujo, Angela Cristina Verissimo Junqueira, Roberta Olmo Pinheiro, Ingebourg Georg, Vitor Barreto Paravidino, Vitor Barreto Paravidino, Tatiana Rehder Gonçalves, Roberto Magalhães Saraiva, Mauro Felippe Felix Mediano, Mauro Felippe Felix Mediano   +22 more
doaj   +1 more source

Immunopathology of Chagas disease [PDF]

Memórias do Instituto Oswaldo Cruz, 1999
The main clinical forms of Chagas disease (acute, indeterminate and chronic cardiac) present strong evidences for the participation of the immune system on pathogenesis. Although parasite multiplication is evident during acute infection, the intense acute myocarditis of this phase exhibits clear ultrastructural signs of cell-mediated immune damage ...
openaire   +5 more sources

Chagas' Heart Disease [PDF]

Clinical Cardiology, 2000
AbstractChagas' disease is caused by a protozoan parasite, Trypanosoma cruzi, that is transmitted to humans through the feces of infected bloodsucking insects in endemic areas of Latin America, or occasionally by nonvectorial mechanisms, such as blood transfusion.
A, Rassi, A, Rassi, W C, Little
openaire   +3 more sources

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

TcI isolates of Trypanosoma cruzi exploit the antioxidant network for enhanced intracellular survival in macrophages and virulence in mice [PDF]

, 2016
Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, the TcI strains Colombiana (COL),
Basombrío, Miguel Ángel Manuel, Dhiman, Monisha, Garg, Nisha J., Hosakote, Yashoda M., Koo, Sue Jie, Parodi­ Talice, Adriana, Piñeyro, María Dolores, Robello, Carlos, Zago, María Paola   +8 more
core   +2 more sources

Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America

Expert Review of Anti-Infective Therapy, 2019
Introduction: Chagas disease, caused by infection with the parasite Trypanosoma cruzi, represents a huge public health problem in the Americas, where millions of people are affected.
Julio Alonso-Padilla, Nuria Cortes-Serra, M. Pinazo, M. Bottazzi, M. Abril, Fabiana Barreira, S. Sosa-Estani, P. Hotez, J. Gascón   +8 more
semanticscholar   +1 more source