Results 101 to 110 of about 308,735 (293)

齿形链传动的模态仿真分析

open access: yesJixie chuandong, 2007
Silent chain drive is a kind of transmission mechanism with a lot of flexible plates. It is difficult to calculate the natural frequencies of silent chain drive accurately because of the discontinuity of its structure and the polygonal effect.
王勇, 朱冬伟, 薛云娜
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Chain Drive Computional Model as Virtual Engine Module

open access: yes, 2010
his work deals with the methods of creating computational models for the analysis of the chain drive of camshafts in combustion engines. Methods are compared of the simulation of the drive mechanism; a new method is also presented for the simulation of ...
Vlastník, Jan
core  

Camshaft Drive Torque Measuring Device Built in a Chain Sprockt

open access: yes, 2012
A device built in a camshaft drive chain sprocket for detecting precise torque fluctuation with minimum change on the valve drive system dynamical characteristics was developed. Strain gages are placed on thin plate areas in the sprocket disc. The signal
Masao Ishihama   +2 more
core   +1 more source

基于多刚体动力学的新型链轮啮合特性分析

open access: yesJixie chuandong, 2008
In order to study the effect of new sprocket for timing roller chain drive,dynamic simulations are carried out respectively about four timing roller chain drive systems in which four sprockets are exploited respectively such as ISO-606 sprocket,JIS-B1802
顾仁涛, 王勇
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Calculation Method of Driving Force of the Plate Quantitative Conveyor Chain Drive System

open access: yes, 2015
For improving the stability and security when the plate quantitative conveyor start-up and the accelerating operation,the calculation problem of driving force of chain drive system is studied.The maximum static tension of the chain drive system on stable
Xi Qiming   +3 more
core   +1 more source

Design and Study of Pre-stretching and Disassembling Device for Double-row Chain

open access: yesJixie chuandong, 2019
Aiming at the pre-stretching and disassembling link in the manufacturing process of double-row chain, a new type of pre-stretching and disassembling device for double-row chain is designed.
Wang Shukun   +4 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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