Results 111 to 120 of about 308,735 (293)

Drive chain friction characterization of a 6DOF parallel kinematics robot

open access: yes, 2019
This paper describes a time-efficient method for friction characterization on a Robot drive chain, namely a Ball-screw transmission. The Method promotes practical application by being independent from external sensors and giving very precise and usable ...
Raineri I.   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Chain conveyor drive for passenger transport

open access: yes, 2018
Tato bakalářská práce pojednává o návrhu konstrukce pohonné jednotkyřetězového dopravníku pro dopravu osob, přesněji eskalátoru. V teoretické části jeblíže popsán princip mechanismu pohonu eskalátorů, jejich funkce, základníparametry a aktuální nabídka ...
Havlíček, Matěj
core  

STUDY ON SIMULATION OF CHAIN DRIVE’DYNAMIC BEHAVIOR BASED ON RECURDYN

open access: yesJixie qiangdu, 2017
Chain drive is a convenient mechanical transmission for use,which has such characteristics as compact structure and high reliability.Chain is a flexible body.In the course of transmission,the polygon effect and the meshing impact are the fundamental ...
TAO DongBo   +3 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A Three R Approach for Supply Chain Business Intelligence

open access: yes, 2007
Today, manufacturing enterprises are required to improve their competitive performance by establishing effective controls over the complex processes and datasets, both internal and external, which drive their business.
Little, David   +3 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Supply chain management tools and methods

open access: yes
In today's business environment, manufacturers need to manage their enterprises as an inseparable part of a supply chain. Key to achieving this is the creation of an extended and integrated information system.
Ivanova, Ivelina
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

A Study on Finite Element Method of Sidebar of Oftset Drive China

open access: yesJixie chuandong, 1995
The offset dried chain is a kind of engineering steel chain which always works in rugged environments. It is important to analyze the mechanics properties of sidebar.
董华明, 王淑云, 王义行
doaj  

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