Results 151 to 160 of about 2,018,011 (296)

Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening. [PDF]

Protein Sci
Fröhlich M, Radišković T, Hopl V, Prantl M, Najjar H, Harant S, Thallinger D, Anwar MS, Horvath F, Söllner J, Nazarenko Y, Sallinger M, Müller N, Tiffner A, Weiß S, Grabmayr H, Krobath H, Derler I.   +17 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The power of Store brands: Intrinsic loyalty and conquesting power. [PDF]

An important evolution in the retailing industry is the growing success of store brands. Still, their level of penetration varies widely across countries and industries.
Steenkamp, J.B., Dekimpe, Marnik
core  

Quantitative Analysis of Axonal Degeneration and TDP-43 Aggregation in Compartmentalized Human iPSC-Derived Motor Neuron-Myotube Co-cultures. [PDF]

Bio Protoc
Subramaniam AG, de Andrade Gensas LK, Gradus-Pery T, Perlson E.   +3 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

U.S. CHAIN RESTAURANT EFFICIENCY [PDF]

The growth of corporate food service firms and the resulting competition places increasing pressures on available resources and their efficient usage. This analysis measures efficiencies for U. S.
Byrne, Patrick J., Barber, David L.
core  

An overview of mobile health applications (mHealth apps) supporting Tuberculosis elimination efforts. [PDF]

Front Digit Health
Nagarajan K, Rajamani N, Muniappan S, Jeyachithra AV, Santhoshkumar Y, Verma A, Stephen A, Muniyandi M.   +7 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Food Environment Assessment in Two Socioeconomic Contexts in Queensland, Australia. [PDF]

Health Promot J Austr
Kadariya S, Parkinson J, Ball L.
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source