Results 231 to 240 of about 2,018,011 (296)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Acid-sensing ion channels in the vasculature: emerging roles in systemic and pulmonary circulations. [PDF]

Pflugers Arch
Jernigan NL.
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Self-reported exposure and reactions to cigarette corrective statements at the point-of-sale among US adults who smoke and youth. [PDF]

Tob Control
Wackowski OA, Mercincavage M, Diaz D, Weiger CV, Delnevo CD, Giovenco DP.   +5 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Effect of food swap recommendations on the healthfulness and carbon footprint of grocery purchases in a naturalistic online store: A randomized parallel trial. [PDF]

PLoS Med
Grummon AH, O'Sullivan K, Zeitlin AB, Taillie LS, Lee CJY, Walker AJ, Tiefenbeck V, Fleisch E, Ulm C, Robinson TN.   +9 more
europepmc   +1 more source

Distribution and Time Trends of Refractive Errors in Japanese Spectacle Wearers. [PDF]

Invest Ophthalmol Vis Sci
Kawasaki R, Matsuoka H, Hori K, Koh S, Nishida K.   +4 more
europepmc   +1 more source

Barriers of last mile supply chain management and reproductive, maternal, new born, and child health product availability in Ethiopia. [PDF]

PLoS One
Mulatu WN, Onyango DK, Mberesero H, Tadelle G, Emaway D, Mesfin B, Shewangizaw T, Tesfaye C, Ababu A, Bogale B, Mogesi K.   +10 more
europepmc   +1 more source

Challenges and Practices in Perishable Food Supply Chain Management in Remote Indigenous Communities: A Scoping Review and Conceptual Framework for Enhancing Food Access. [PDF]

Int J Environ Res Public Health
Gharakhani Dehsorkhi B, Afif K, Doyon M.
europepmc   +1 more source

Trends in the Range of Zero Alcohol Products Available in Supermarkets and Alcohol Stores in Australia. [PDF]

Drug Alcohol Rev
Pettigrew S, Davies T, Sträuli B, Yusoff A, O'Brien P, Jongenelis M, Brownbill A, Jones A, Taylor F, Bowen J.   +9 more
europepmc   +1 more source