Results 191 to 200 of about 7,880,129 (337)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Longitudinal Interaction Between Individualized Gut Microbial Dynamics and Diet Is Associated with Metabolic Health in School-Aged Children. [PDF]

Nutrients
Feng C, Yang M, Yang Z, Liao X, Jiang S, Li L, Lin H, Sun Y, Wei Z, Weng Z, Wu D, Zhang L, Wine E, Madsen KL, Deehan EC, Li J, Zeng J, Liu J, Zhang Z, Cai C.   +19 more
europepmc   +1 more source

Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.

American Journal of Human Genetics, 2004
Jingshan Chen, B. Lipska, N. Halim, Quang D Ma, M. Matsumoto, Samer Melhem, B. Kolachana, T. Hyde, M. Herman, J. Apud, M. Egan, J. Kleinman, D. Weinberger   +12 more
semanticscholar   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Systematic design of polybasic nanogels: influence of hydrophobic monomers on tunable physicochemical and biological properties. [PDF]

NPJ Biomed Innov
Wagner AM, Duggal I, Lawrence A, Shearer A, Schroeder A, Al-Sayyad N, Rodriguez-Cruz JJ, Villarreal FAC, Peppas NA.   +8 more
europepmc   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Diversify and conquer: How effector diversity is shaped by host-microbe co-evolution. [PDF]

PLoS Pathog
Müller MC, Brumm S, Hu Y, Kemen E, Lahaye T, Hückelhoven R.   +5 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

VACmap: an accurate long-read aligner for unraveling complex genomic rearrangements. [PDF]

Nat Commun
Ding H, Sedlazeck FJ, Proukakis C, Morley C, Toffoli M, Schapira AH, Liao Z, Pu L, Zhu S.   +8 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source