Results 111 to 120 of about 10,987,289 (344)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Corrigendum: Levulinic Acid Biorefineries: New Challenges for Efficient Utilization of Biomass [PDF]
, 2016 Filoklis D. Pileidis +1 more
openalex +1 more source
Challenges of integration and globalization [PDF]
, 2011 There has been plenty of books and articles written about integration and globalisation, especially in English. However, these processes are characterised as being extremely dynamic.
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Revista de Lenguas para Fines Específicos, 2005 En este trabajo se presentan diferentes estrategias en la enseñanza de una lengua extranjera. Ellos se basan en una metodología audiovisual. Por un lado, el alumno siente el lenguaje vivo desde el principio, y de forma paralela, desempeña un papel activo papel en su aprendizaje.
openaire +4 more sources
Ultra-high-performance fiber-reinforced concrete: Challenges
, 2022 Shaker Qaidi
openalex +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Pharmacotherapy of neuropsychiatric symptoms: opportunities, challenges and current prospects [PDF]
, 2007 Peter V. Rabins, Constantine G. Lyketsos
openalex +1 more source