Results 121 to 130 of about 10,539,337 (290)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Comprehensive review of One Health systems for emerging infectious disease detection and management

One Health
This systematic review investigates how One Health systems, integrated digital platforms combining human, animal, and environmental health data, are currently designed and implemented for infectious disease detection and management.
Aseel Basheer, Matthew Tran, Baseer Khan, Wolfgang Jentner, Aaron Wendelboe, Jason Vogel, Katrin Kuhn, Michael C. Wimberly, David Ebert   +8 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Multi-objective optimization of DU bed for hydriding performance and heat management based on data-driven surrogate model

Case Studies in Thermal Engineering
The Storage and Delivery System (SDS) of ITER is responsible for the controlled charging and discharging of hydrogen isotopes, requiring reliable and efficient metal hydride storage technology.
Hanseul Lee, Jaeyoo Choi, Yujin Kim, Jihoon Park, Yeji Han, Hyun-Goo Kang, Junyoung Hur, Hyunchul Ju   +7 more
doaj   +1 more source

PDOL-Based Solid Electrolyte Toward Practical Application: Opportunities and Challenges [PDF]

Hua Yang, Mao‐xiang Jing, Li Wang, Hong Xu, Xiaohong Yan, Xiangming He   +5 more
openalex   +1 more source

Constructive Learning Approach in Mathematics Education: Challenges and Possibilities

, 2021
Bhim Bahadur Rokaya
openalex   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Granular Cell Tumor of Cecum: A Common Tumor in a Rare Site with Diagnostic Challenge [PDF]

, 2017
Meyyappa Devan Rajagopal, Debasis Gochhait, Dasarathan Shanmugan, Adarsh Barwad   +3 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source