Results 161 to 170 of about 10,539,337 (290)

Experiences and challenges of early career researcher investigating youth suicidality in Nepal. [PDF]

Discov Ment Health
Sigdel K, Shrestha S, Sharma N, Sharma RH, Hagaman AK.   +4 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

INNOVATIONS IN EDUCATION: PROSPECTS AND CHALLENGES OF TODAY

Denis Vladlenov, Denis Vladlenov
openalex   +1 more source

The match between institutional elderly care management research and management challenges - a systematic literature review [PDF]

, 2012
Kaija Kokkonen, Sari Rissanen, Anneli Hujala   +2 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Strengthening primary health care service competency: a scoping review of challenges, influencing factors, and enhancement strategies. [PDF]

Front Public Health
Yang S, Bai C, Zhao Y, Wang J, Jin H, Harris-Roxas B, Liu Y, Shen F, Zhao H, Ma L, Shi L, Yu D.   +11 more
europepmc   +1 more source

Yugoslavia: post-electoral challenges [PDF]

, 2000
Ralchev, Plamen
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Challenges and barriers in managing Type 2 diabetes: insights from a qualitative study of patients' experiences at a university hospital in Qassim, Saudi Arabia. [PDF]

Glob Health Action
Ngo AD, Kulintang MB, Alharbi TAF, Hussein RM, Al-Najjar H, Majed Alharbi F, Algeffari M, Sawan YH.   +7 more
europepmc   +1 more source