Results 141 to 150 of about 4,304,349 (326)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

ENTROPİ, ŞANS VE TANRI

Felsefe Dünyası, 2014
Evrenin bir başlangıcının olup olmadığı ya da bu düzenin nereden geldiğigibi sorular, insanlığın en büyük merakıdır. Fakat 18. Yüzyılda sanayi devrimininürünü olan buhar makinelerinin çalışma prensiplerinin keşfiyle birlikte doğan termodinamikve ...
Fatih Özgökman
doaj  

Measurement of HO2 and other trace gases in the stratosphere using a high resolution far-infrared spectrometer at 28 KM [PDF]

The major events and results to date of the ongoing program of measuring stratospheric composition by the technique of far-infrared Fourier-transform spectroscopy from a balloon-borne platform are reviewed.
Chance, Kelly V., Traub, Wesley A.
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

ARİSTOTELES VE FARABİ'NİN FELSEFESİNDE RASTLANTININ YERİ

Felsefe Dünyası, 2005
İsmail ERDOĞAN, ARİSTOTELES VE FARABİ'NİN FELSEFESİNDE RASTLANTININ ...
İsmail Erdoğan
doaj  

Second chances [PDF]

Nature, 2016
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

MAQUIAVELO: LA LEGALIZACIÓN DEL AZAR AL SERVICIO DE LA REPÚBLICA FLORENTINA

Daimon
A partir de la elucidación de los influjos cristianos sobre el pensamiento político de Nicolas Maquiavelo, la autora rastrea el fondo epistemológico que subyace a sus propuestas, consistente en la transformación del azar, con el que se identificaba la ...
Carmen Hidalgo Roldán
doaj  

On multi-criteria chance-constrained capacitated single-source discrete facility location problems

, 2018
Ömer Burak Kınay, Francisco Saldanha‐da‐Gama, Bahar Y. Kara   +2 more
openalex   +2 more sources