Results 141 to 150 of about 1,349,138 (341)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Stoch-aptation: a new term in the science of evolution
Ideas in Ecology and Evolution, 2015 Following two seminal papers published in Paleobiology by Stephen Jay Gould and Elisabeth Vrba several decades ago, I suggest a new term (stoch-aptation) to refer to those individual traits or sets of traits that provide, just by chance, fitness ...
Alejandro Martínez Abraín
doaj
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Hume e as bases científicas da tese de que não há acaso no mundo
Principia: An International Journal of Epistemology, 2012 Both in the Treatise of Human Nature and in the Enquiry concerning Human Understanding, Hume defends that “there is no chance in the world”, and that “what the vulgar call chance is nothing but a secret and conceal’d cause”.
Silvio Seno Chibeni
doaj
Withholding interferon‐α from patients with chronic myeloid leukaemia prior to bone marrow examination does not improve the chance of a successful cytogenetic analysis [PDF]
, 2004 Anthony P. Schwarer +4 more
openalex +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source