Results 141 to 150 of about 4,254,908 (281)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Seasonal soybean crop reflectance [PDF]
Data are presented from field measurements of 1980 including 5 acquisitions of handheld radiometer reflectance measurements, 7 complete sets of parameters for implementing the Suits mode, and other biophysical parameters to characterize the soybean ...
Chance, J. E., Lemaster, E. W.
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Научный вестник МГТУ ГА, 2016 The article deals with methods of forecasting the level of aviation safety operation of aircraft systems on the basis of methods of evaluation the risks of negative situations as a consequence of a functional loss of initial properties of the system with
E. A. Kuklev
doaj
Measurement of HO2 and other trace gases in the stratosphere using a high resolution far-infrared spectrometer at 28 KM [PDF]
The major events and results to date of the ongoing program of measuring stratospheric composition by the technique of far-infrared Fourier-transform spectroscopy from a balloon-borne platform are reviewed.
Chance, Kelly V., Traub, Wesley A.
core +1 more source